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TABLE OF CONTENTS

  • INTRODUCTION
  • ALDOSTERONE BIOSYNTHESIS
  • REGULATION OF ALDOSTERONE SECRETION
  • The Renin-Angiotensin system
  • Potassium
  • Pituitary Factors
  • Sodium
  • Inhibitory agents
  • MECHANISMS OF ALDOSTERONE ACTION
  • Effect of Aldosterone
  • Mineralocorticoid Receptor
  • Molecular and Cellular Mechanisms of the Aldosterone Action
  • Pre-receptor Regulation
  • Amiloride-sensitive sodium channel
  • CLASSIFICATION OF HYPOALDOSTERONISM
  • Defective Stimulation of Aldosterone
  • Primary Defects in Adrenal Biosynthesis or Secretion of Aldosterone
  • Defective Aldosterone Actions
  • HYPORENINEMIC HYPOALDOSTERONISM
  • Presentation
  • Pathophysiology
  • Diagnosis
  • Therapy
  • PRIMARY HYPOALDOSTERONISM
  • (Aldosterone Synthase) Deficiency
  • Clinical Presentation
  • Diagnosis and Therapy
  • Molecular mechanisms of CYP11B2 deficiency
  • Acquired form of primary hypoaldosteronism
  • TYPE 1 (ALDOSTERONE RESISTANCE )
  • Clinical Presentation
  • Pathophysiology
  • Diagnosis
  • Therapy
  • Molecular Mechanism(s) of Pseudohypoaldosteronism