Table of Contents

INTRODUCTION

STRUCTURE OF GR GENE AND PROTEIN

TRANSCRIPTIONAL AND TRANSLATIONAL REGULATION OF GR ISOFORMS

ACTION OF GR

Nucleocytoplasmic Shuttling of GRα

Mechanisms of Transcriptional Activation by GRα

Interaction of GR with Other Transcription Factors

FACTORS THAT MODULATE GR ACTION

New Ligands with Selective Activities

11 β-Hydroxysteroid Dehydrogenases (11β-HSDs)

Phosphorylation of the GR

Chaperones and Cochaperones

Ubiquitination of GR and Components of the Transcriptional Initiation Complex

14-3-3 Proteins

Chemicals and Other Compounds

PATHOLOGIC MODULATION OF GR ACTIVITY

GR Polymorphisms

GRβ

Viral Infection