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TABLE OF CONTENTS

  • INTRODUCTION
  • RISK FACTORS FOR BONE LOSS
  • INDIVIDUAL SUSCEPTIBILITY TO GCOP
  • CELLULAR AND MOLECULAR MECHANISMS OF GCOP
  • Bone histomorphometry under GCs
  • Glucocorticoid receptors (GRs) and bone
  • GCs and osteoblast activity
  • GCs and osteoclast activity
  • GCs and local bone factors (cytokines, growth factors and prostanoids)
  • EXTRASKELETAL ACTIONS OF GLUCOCORTICOIDS
  • Medical history and clinical evaluation
  • Laboratory tests and markers of bone turnover
  • Bone Mineral Density (BMD) Assessment
  • PREVENTION AND TREATMENT OF GCOP
  • General preventive strategies
  • THERAPY OF GCOP
  • FUTURE THERAPEUTIC OPTIONS
  • REVERSIBILITY OF GCOP