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Introduction
Early Insulin Replacement in Type 2 diabetes –The Rationale
Effects of Insulin Therapy on Insulin Resistance
Potential Cardioprotective Effects of Insulin Therapy
Barriers to Insulin Therapy
Weight Gain
Hypoglycemia
Limitations of Traditional Human Insulin Formulations
Mechanical Barriers
Misconception of Increased Cardiovascular Risk
Physiologic Insulin Replacement – The Basal/Bolus Concept
Initiating Insulin Therapy with Basal Insulin
Initiating Insulin Therapy with Bolus Insulin
Insulin Replacement Therapy – Practical Guidelines
Practical Guidelines For Starting Basal Insulin
Practical Guidelines for Advancing to Basal–Bolus Therapy
The Future of Insulin Therapy in Type 2 Diabetes
