1. Kimball C, Murlin J 1923 Aqueous extracts of pancreas III. Some precipitation reactions of insulin. J Biochem 58:337-348

2. Bromer W, Winn L, Behrens O 1957 The amino acid sequence of glucagon V. Location of amide groups, acid degradation studies and summary of sequential evidence. J Am Chem Soc 79:2807-2810

3. Sutherland E, Robison G, Butcher R 1968 Some aspects of the biological role of adenosine 3',5'-monophosphate (cyclic AMP). Circulation 37:279-306

4. Gerich J 1981 Physiology of glucagon. Int Rev Physiol 24:244-275

5. Gerich J, Lovinger R, Grodsky G 1975 Inhibition by somatostatin of glucagon and insulin release from the perfused rat pancreas in response to arginine, isoproterenol, and theophylline: evidence for a preferential effect on glucagon secretion. Endocrinology 96:749-754

6. Patzelt C, Schiltz E 1984 Conversion of proglucagon in pancreatic alpha cells: the major endproducts are glucagon and a single peptide, the major proglucagon fragment, that contains two glucagon-like sequences. Proc Natl Acad Sci U S A 81(16):5007-5011

7. Conlon JM 1980 The glucagon-like polypeptides - order out of chaos? Diabetologia 18(2):85-88

8. Weir G 1981 Glucagon in normal physiology and diabetes mellitus. In: Brownlee E, ed. Diabetes Mellitus. New York: Garland STPM Press; 207-259

9. Jaspan JB, Rubenstein AH 1977 Circulating glucagon. Plasma profiles and metabolism in health and disease. Diabetes 26(9):887-904

10. Brockman RP, Manns JG, Bergman EN 1976 Quantitative aspects of secretion and hepatic removal of glucagon in sheep. Can J Physiol Pharmacol 54(5):666-670

11. Rojdmark S, Bloom G, Chou MC, Jaspan JB, Field JB 1978 Hepatic insulin and glucagon extraction after their augmented secretion in dogs. Am J Physiol 235(1):E88-E96

12. Emmanouel D, Jaspan J, Rubenstein A, Huen A, Fink E, Katz A 1978 Glucagon metabolism in the rat: contribution of the kidney to the metabolic clearance rate of the hormone. J Clin Invest 62:6-13

13. Jaspan JB, Huen AH, Morley CG, Moossa AR, Rubenstein AH 1977 The role of the liver in glucagon metabolism. J Clin Invest 60(2):421-428

14. Rojdmark S, Bloom G, Chou MC, Field JB 1978 Hepatic extraction of exogenous insulin and glucagon in the dog. Endocrinology 102(3):806-813

15. Blackard W, Nelson N, Andrews S 1974 Portal and peripheral vein immunoreactive glucagon concentrations after arginine or glucose infusions. Diabetes 23:199-202

16. Felig P, Gusberg R, Hendler R, Gump F, Kinney J 1974 Concentrations of glucagon and the insulin : glucagon ratio in the portal and peripheral circulation. Proc Soc Exp Biol Med 147:88-90

17. Dencker M, Hedner P, Holst J, Tranberg K 1975 Pancreatic glucagon response to an ordinary meal. Scand J Gastroenterol 10:471-474

18. Kuku S, Jaspan J, Emmanouel D, Zeidler A, Katz A, Rubenstein A 1976 Heterogeneity of plasma glucagon: circulating components in normal subjects and patients with chronic renal failure. J Clin Invest 58:742-750

19. Noe BD, Bauer GE, Steffes MW, Sutherland DE, Najarian JS 1975 Glucagon biosynthesis in human pancreatic islets: preliminary evidence for a biosynthetic intermediate. Horm Metab Res 7(4):314-322

20. Weir GC, Horton ES, Aoki TT, Slovik D, Jaspan J, Rubenstein AH 1977 Secretion by glucagonomas of a possible glucagon precursor. J Clin Invest 59(2):325-330

21. Valverde I, Lemon HM, Kessinger A, Unger RH 1976 Distribution of plasma glucagon immunoreactivity in a patient with suspected glucagonoma. J Clin Endocrinol Metab 42(5):804-808

22. Recant L, Perrino PV, Bhathena SJ, Danforth DN, Jr., Lavine RL 1976 Plasma immunoreactive glucagon fractions in four cases of glucagonoma: increased "large glucagon-immunoreactivity". Diabetologia 12(4):319-326

23. Tasaka Y, Inoue S, Hirata Y, Hanyu F, Endo M 1981 Time course of content of insulin, glucagon and pancreatic polypeptide in human pancreatic tissue obtained by surgery. Endocrinol Jpn 28(3):261-264

24. Rastogi GK, Sinha MK, Dash RJ 1973 Insulin and proinsulin content of pancreases from diabetic and nondiabetic subjects. Diabetes 22(11):804-807

25. Carpentier JL, Malaisse-Lagae F, Muller WA 1977 Glucagon release from rat pancreatic islets. A combined morphological and functional approach. J Clin Invest 60(5):1174-1182

26. Gerich J, Charles M, Grodsky G 1976 Regulation of pancreatic insulin and glucagon secretion. Ann Rev Physiol 38:353-388

27. Toyota T, Sato SI, Kudo M, Abe K, Goto Y 1975 Secretory regulation of endocrine pancreas: Cyclic AMP and glucagon secretion. J Clin Endocrinol Metab 41(1):81-89

28. Bokvist K, Olsen HL, Hoy M, Gotfredsen CF, Holmes WF, Buschard K, Rorsman P, Gromada J 1999 Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells. Pflugers Arch 438(4):428-436

29. Carpentier JL, Sawano F, Ravazzola M, Malaisse WJ 1986 Internalization of 3H-glibenclamide in pancreatic islet cells. Diabetologia 29(4):259-261

30. Grodsky GM, Epstein GH, Fanska R, Karam JH 1977 Pancreatic action of the sulfonylureas. Fed Proc 36(13):2714-2719

31. Hoy M, Olsen HL, Bokvist K, Buschard K, Barg S, Rorsman P, Gromada J 2000 Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (KATP) conductance in rat pancreatic A-cells. J Physiol 527 Pt 1:109-120

32. Fisher M, Sherwin RS, Hendler R, Felig P 1976 Kinetics of glucagon in man: effects of starvation. Proc Natl Acad Sci U S A 73(5):1735-1739

33. Alford F, Bloom S, Nabarro J 1976 Glucagon metabolism in man: studies on the metabolic clearance rate and the plasma acute disappearance time of glucagon in normal and diabetic subjects. J Clin Endo & Metab 42:830-838

34. Sherwin R, Fisher M, Bessoff J, Snyder N, Hendler R, Conn H, Felig P 1978 Hyperglucagonemia in cirrhosis: altered secretion and sensitivity to glucagon. Gastroenterology 74:1224-1228

35. Sherwin R, Bastl C, Finkelstein F, Fisher M, Black H, Hendler R, Felig P 1976 Influence of uremia and hemodialysis on the turnover and metabolic effects of glucagon. J Clin Invest 57:722-731

36. Lefebvre P, Luykx A, Nizet A 1974 Renal handling of endogenous glucagon in the dog: comparison with insulin. Metabolism 23:753-760

37. Bastl C, Finkelstein F, Sherwin R, Hendler R, Felig P, Hayslett J 1977 Renal extraction of glucagon in rats with normal and reduced renal function. Am J Physiol 233:67-71

38. Emmanouel D, Jaspan J, Kuku S, Rubenstein A, Katz A 1976 Pathogenesis and characterization of hyperglucagonemia in the uremic rat. J Clin Invest 58:1266-1271

39. Gerich J, Charles M, Grodsky G 1974 Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas. J Clin Invest 54:833-841

40. Mitrakou A, Ryan C, Veneman T, Mokan M, Jenssen T, Kiss I, Durrant J, Cryer P, Gerich J 1991 Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol 260:E67-E74

41. Rocha DM, Faloona GR, Unger RH 1972 Glucagon-stimulating activity of 20 amino acids in dogs. J Clin Invest 51(9):2346-2351

42. Gerich J, Langlois M, Schneider V, Karam J, Noacco C 1974 Effects of alterations of plasma free fatty acid levels on pancreatic glucagon secretion in man. J Clin Invest 53:1284-1289

43. Goberna R, Tamarit J, Jr., Osorio J, Fussganger R, Tamarit J, Pfeiffer EF 1974 Action of B-hydroxy butyrate, acetoacetate and palmitate on the insulin release in the perfused isolated rat pancreas. Horm Metab Res 6(4):256-260

44. Gerich J, Karam J, Forsham P 1973 Stimulation of glucagon secretion by epinephrine in man. J Clin Endocrinol Metab 37:479-481

45. Iversen J 1973 Effect of acetyl choline on the secretion of glucagon and insulin from the isolated, perfused canine pancreas. Diabetes 22(5):381-387

46. Marliss EB, Girardier L, Seydoux J, Wollheim CB, Kanazawa Y, Orci L, Renold AE, Porte D, Jr. 1973 Glucagon release induced by pancreatic nerve stimulation in the dog. J Clin Invest 52(5):1246-1259

47. Kaneto A, Kosaka K, Nakao K 1967 Effects of stimulation of the vagus nerve on insulin secretion. Endocrinology 80(3):530-536

48. Unger RH, Ketterer H, Dupre J, Eisentraut AM 1967 The effects of secretin, pancreozymin, and gastrin on insulin and glucagon secretion in anesthetized dogs. J Clin Invest 46(4):630-645

49. Pederson RA, Brown JC 1978 Interaction of gastric inhibitory polypeptide, glucose, and arginine on insulin and glucagon secretion from the perfused rat pancreas. Endocrinology 103(2):610-615

50. Santeusanio F, Faloona GR, Unger RH 1972 Suppressive effect of secretin upon pancreatic alpha cell function. J Clin Invest 51(7):1743-1749

51. Goldfine ID, Kirsteins L, Lawrence AM 1972 Excessive glucagon responses to arginine in active acromegaly. Horm Metab Res 4(2):97-100

52. Wise JK, Hendler R, Felig P 1973 Influence of glucocorticoids on glucagon secretion and plasma amino acid concentrations in man. J Clin Invest 52(11):2774-2782

53. Seino Y, Goto Y, Taminato T, Ikeda M, Imura H 1974 Plasma insulin and glucagon responses to arginine in patients with thyroid dysfunction. J Clin Endocrinol Metab 38(6):1136-1140

54. Marliss E, Aoki T, Unger R, Soeldner J, Cahill G 1970 Glucagon levels and metabolic effects in fasting man. J Clin Invest 49:2256-2270

55. Lewis S, Wallin J, Kane J, Gerich J 1977 Effect of diet composition on metabolic adaptations to hypocaloric nutrition: comparison of high carbohydrate and high fat isocaloric diets. Am J Clin Nutr 30:160-170

56. Kalkoff R, Gossain V, Maktute M 1973 Plasma glucagon in obesity. N Engl J Med 289:465-467

57. Cryer P 1996 Glucagon and glucose counterregulation. In: Lefèbvre P, ed. Glucagon I. Berlin: Springer-Verlag; 149-158

58. Carlson MG, Snead WL, Campbell PJ 1993 Regulation of free fatty acid metabolism by glucagon. J Clin Endocrinol Metab 77(1):11-15

59. Exton J, Park C 1972 Interaction of insulin and glucagon in the control of liver metabolism. In: Steiner D, Freinkel N, eds. Endocrine Pancreas, Section 7, Handbook of Physiology. Baltimore: Williams and Wilkins; 437-455

60. Gerich J, Schneider V, Dippe S, Langlois M, Noacco C, Karam J, Forsham P 1974 Characterization of the glucagon response to hypoglycemia in man. J Clin Endocrinol Metab 38:77-82

61. Galbo H, Holst JJ, Christensen NJ 1975 Glucagon and plasma catecholamine responses to graded and prolonged exercise in man. J Appl Physiol 38(1):70-76

62. Wilmore DW, Lindsey CA, Moyland JA, Faloona GR, Pruitt BA, Unger RH 1974 Hyperglucagonaemia after burns. Lancet 1(7847):73-75

63. Rocha DM, Santeusanio F, Faloona GR, Unger RH 1973 Abnormal pancreatic alpha-cell function in bacterial infections. N Engl J Med 288(14):700-703

64. Willerson JT, Hutcheson DR, Leshin SJ, Faloona GR, Unger RH 1974 Serum glucagon and insulin levels and their relationship to blood glucose values in patients with acute myocardial infarction and acute coronary insufficiency. Am J Med 57(5):747-752

65. Gerich J, Davis J, Lorenzi M, Rizza R, Bohanan N, Karam J, Lewis S, Kaplan S, Schultz T, Cryer P 1979 Hormonal mechanisms of recovery from insulin-induced hypoglycemia in man. Am J Physiol 236:E380-E385

66. Rizza R, Cryer P, Gerich J 1979 Role of glucagon, catecholamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined a- and b-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia. J Clin Invest 64:62-71

67. Garber A, Cryer P, Santiago J, Haymond M, Pagliara A, Kipnis D 1976 The role of adrenergic mechanisms in the substrate and hormonal response to insulin-induced hypoglycemia in man. J Clin Invest 58:7-15

68. Feldman J, Plonk J, Bivens C 1975 The role of cortisol and growth hormone in the counterregulation of insulin-induced hypoglycemia. Horm Metab Res 7:378-381

69. Lecavalier L, Bolli G, Cryer P, Gerich J 1989 Contributions of gluconeogenesis and glycogenolysis during glucose counterregulation in normal humans. Am J Physiol 256:E844-E851

70. Ohneda A, Watanabe K, Horigome K, Sakai T, Kai Y, Oikawa S 1978 Abnormal response of pancreatic glucagon to glycemic changes in diabetes mellitus. J Clin Endocrinol Metab 46(3):504-510

71. Shah P, Vella A, Basu A, Basu R, Schwenk WF, Rizza RA 2000 Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus. J Clin Endocrinol Metab 85(11):4053-4059

72. Shah P, Basu A, Basu R, Rizza R 1999 Impact of lack of suppression of glucagon on glucose tolerance in humans. Am J Physiol 277:E283-E290

73. Dinneen S, Alzaid A, Turk D, Rizza R 1995 Failure of glucagon suppression contributes to postprandial hyperglycaemia in IDDM. Diabetologia 38:337-343

74. Mitrakou A, Kelley D, Mokan M, Veneman T, Pangburn T, Reilly J, Gerich J 1992 Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 326:22-29

75. Baron A, Schaeffer L, Shragg P, Kolterman O 1987 Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics. Diabetes 36:274-283

76. Ahren B, Larsson H 2001 Impaired glucose tolerance (IGT) is associated with reduced insulin-induced suppression of glucagon concentrations. Diabetologia 44(11):1998-2003

77. Felig P, Wahren J, Hendler R 1975 Influence of oral glucose ingestion of splanchnic glucose and gluconeogenic substrate mechanism in man. Diabetes 24:468-475

78. Kelley D, Mitrakou A, Marsh H, Schwenk F, Benn J, Sonnenberg G, Archangeli M, Aoki T, Sorensen J, Berger M, Sonksen P, Gerich J 1988 Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load. J Clin Invest 81:1563-1571

79. Gerich J, Lorenzi M, Karam J, Schneider V, Forsham P 1975 Abnormal pancreatic glucagon secretion and postprandial hyperglycemia in diabetes mellitus. JAMA 234:159-165

80. Miles J, Rizza R, Haymond M, Gerich J 1979 Effects of acute insulin deficiency and administration on ketone body and glucose turnover in man. Clin Res 27:658

81. Witters LA, Trasko CS 1979 Regulation of hepatic free fatty acid metabolism by glucagon and insulin. Am J Physiol 237(1):E23-E29

82. McGarry J, Takabayashi Y, Foster D 1978 The role of malonyl-CoA in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes. J Biochem 253:8294-8300

83. Schade DS, Eaton RP 1975 Modulation of fatty acid metabolism by glucagon in man. I. Effects in normal subjects. Diabetes 24(5):502-509

84. Rodbell M 1983 The actions of glucagon at its receptor. In: Lefebvre P, ed. Glucagon I. Berlin: Springer-Verlag; 263-290

85. Baetens D, Malaisse-Lagae F, Perrelet A, Orci L 1979 Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans. Science 206(4424):1323-1325

86. McGarry J, Foster D 1983 Glucagon and ketogenesis. In: Lefebvre P, ed. Glucagon I. Berlin: Springer-Verlag; 383-398

87. Unger RH, Orci L 1976 Physiology and pathophysiology of glucagon. Physiol Rev 56(4):778-826

88. Unger R 1978 Role of glucagon in the pathogenesis of diabetes: the status of the controversy. Metabolism 27:1691-1709

89. Muller WA, Faloona GR, Aguilar-Parada E, Unger RH 1970 Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N Engl J Med 283(3):109-115

90. Wahren J, Felig P, Hagenfeldt L 1976 Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. J Clin Invest 57:987-999

91. Unger RH 1973 Normal and abnormal alpha cell function. Annu Rev Med 24:303-308

92. Seino Y, Ikeda M, Kurahachi H, Taminato T, Sakurai H, Goto Y, Inoue Y, Kadowaki S, Mori K, Imura H 1978 Failure to suppress plasma glucagon concentrations by orally administered glucose in diabetic patients after treatment. Diabetes 27(12):1145-1150

93. Raskin P, Fujita Y, Unger RH 1975 Effect of insulin-glucose infusions on plasma glucagon levels in fasting diabetics and nondiabetics. J Clin Invest 56(5):1132-1138

94. Gerich J, Langlois M, Noacco C, Karam J, Forsham P 1973 Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha-cell defect. Science 182:171-173

95. Barnes A, Bloom S 1976 Pancreatectomized man: a model for diabetes without glucagon. Lancet 1:219-221

96. Asplin C, Paquettte T, Palmer J 1981 In vivo inhibition of glucagon secretion by paracrine beta-cell activity in man. J Clin Invest 68:314-318

97. Gerich J, Schultz T, Tsalikian E, Lorenzi M, Lewis S, Karam J 1977 Clinical evaluation of somatostatin as a potential adjunct to insulin in the management of diabetes mellitus. Diabetologia 13:537-544

98. Cryer P 2002 Hypoglycaemia: The limiting factor in the glycaemic management of type I and type II diabetes. Diabetologia 45:937-948