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	OVERVIEW AND HISTORICAL PERSPECTIVE
	A Specific Receptor for Insulin at the Cell Surface
	Insulin Receptor Purification and Subunit Composition
	Hormone Binding to Insulin and IGF Receptors
	The Clinical Significance of IR Isoforms and Hybrids
	Biosynthetic Pathways
	ACTIVATION AND MODULATION OF INSULIN RECEPTOR FUNCTION
	The Insulin Receptor is a Protein Kinase
	Dephosphorylation as a Mechanism to Terminate Insulin Signaling
	Interference with Kinase Activity and Substrate Phosphorylation - Potential Mechanisms of Insulin Resistance
	MOLECULAR BIOLOGY OF THE INSULIN RECEPTOR
	Cloning the Insulin Receptor cDNA and Gene
	Structures for Domains of the Insulin Receptor
	SHIFTS IN PARADIGMS FOR INSULIN RECEPTOR PHYSIOLOGY
	Insulin Receptor Knockouts as Models for Insulin Resistance
	Insulin Receptor Functions in Worms and Flies as Models for Human Physiology and Disease