1.Cohen, P. (2006) Nat Rev Mol Cell Biol 7(11), 867-873

2.Taylor, S. I. (1999) Cell 97(1), 9-12

3.Saltiel, A. R., and Kahn, C. R. (2001) Nature 414(6865), 799-806

4.Goldfine, I. D. (1987) Endocr Rev 8, 235-255

5.White, M. F., and Kahn, C. R. (1994) J Biol Chem 269, 1-4

6.Accili, D., Drago, J., Lee, E. J., Johnson, M. D., Cool, M. H., Salvatore, P., Asico, L. D., Jose, P. A., Taylor, S. I., and Westphal, H. (1996) Nat Genet 12(1), 106-109

7.Joshi, R. L., Lamothe, B., Cordonnier, N., Mesbah, K., Monthioux, E., Jami, J., and Bucchini, D. (1996) Embo J 15(7), 1542-1547

8.Accili, D., Nakae, J., Kim, J. J., Park, B. C., and Rother, K. I. (1999) J Pediatr Endocrinol Metab 12(4), 475-485

9.Taylor, S. I. (1992) Diabetes 41, 1473-1490

10.Olefsky, J. M. (1976) J Clin Invest 57, 1165-1172

11.Caro, J. F., Itoop, O., Pories, W. J., Meelheim, D., Flickinger, E. G., Thomas, F., Jenquin, M., Silverman, J. F., Khazanie, P. G., and Sinha, M. K. (1986) J Clin Invest 78, 249-258

12.Caro, J. F., Sinha, M. K., Raju, S. M., Ittoop, O., Pories, W. J., Flickinger, E. G., Meelheim, D., and Dohm, G. L. (1987) J Clin Invest 79, 1330-1337

13.Goodyear, L. J., Giorgino, F., Sherman, L. A., Carey, J., Smith, R. J., and Dohm, G. L. (1995) J Clin Invest 95, 2195-2204

14.Kerouz, N. J., Horsch, D., Pons, S., and Kahn, C. R. (1997) J Clin Invest 100(12), 3164-3172

15.Krook, A., Roth, R. A., Jiang, X. J., Zierath, J. R., and Wallberg-Henriksson, H. (1998) Diabetes 47(8), 1281-1286

16.Kasuga, M., Karlsson, F. A., and Kahn, C. R. (1982) Science 215, 185-187

17.Rosen, O. M., Herrera, R., Olowe, Y., Petruzzelli, M., and Cobb, M. H. (1983) Proc Natl Acad Sci USA 80, 3237-3240

18.Yu, K. T., and Czech, M. P. (1984) J Biol Chem 259(8), 5277-5286

19.Ellis, L., Morgan, D. O., Clauser, E., Roth, R. A., and Rutter, W. J. (1987) Mol Endocrinol 1, 15-24

20.Luo, R. Z., Beniac, D. R., Fernandes, A., Yip, C. C., and Ottensmeyer, F. P. (1999) Science 285(5430), 1077-1080

21.Ottensmeyer, F. P., Beniac, D. R., Luo, R. Z., and Yip, C. C. (2000) Biochemistry 39(40), 12103-12112

22.Hubbard, S. R. (1997) Embo J 16(18), 5572-5581

23.Hubbard, S. R., Wei, L., Ellis, L., and Hendrickson, W. A. (1994) Nature 372, 746-754

24.Seino, S., and Bell, G. I. (1989) Biochem Biophys Res Commun 159, 312-316

25.Moller, D. E., Yokota, A., Caro, J. F., and Flier, J. S. (1989) Mol Endocrinol 3, 1263-1269

26.Ullrich, A., Bell, J. R., Chen, E. Y., Herrera, R., Petruzzelli, L. M., Dull, T. J., Gray, A., Coussens, L., Liao, Y. C., Tsubokawa, M., Mason, A., Seeburg, P. H., Grunfeld, C., Rosen, O. M., and Ramachandran, J. (1985) Nature 313, 756-761

27.Ebina, Y., Ellis, L., Jarnagin, K., Edery, M., Graf, L., Clauser, E., Ou, J. H., Masiarz, F., Kan, Y. W., Goldfine, I. D., Roth, R. A., and Rutter, W. J. (1985) Cell 40, 747-758

28.McClain, D. A. (1991) Mol Endocrinol 5, 734-739

29.Yamaguchi, Y., Flier, J. S., Yokota, A., Benecke, H., Backer, J. M., and Moller, D. E. (1991) Endocrinology 129, 2058-2066

30.Louvi, A., Accili, D., and Efstratiadis, A. (1997) Dev Biol 189(1), 33-48

31.Sciacca, L., Costantino, A., Pandini, G., Mineo, R., Frasca, F., Scalia, P., Sbraccia, P., Goldfine, I. D., Vigneri, R., and Belfiore, A. (1999) Oncogene 18(15), 2471-2479

32.Frasca, F., Pandini, G., Scalia, P., Sciacca, L., Mineo, R., Costantino, A., Goldfine, I. D., Belfiore, A., and Vigneri, R. (1999) Mol Cell Biol 19(5), 3278-3288

33.Leibiger, B., Leibiger, I. B., Moede, T., Kemper, S., Kulkarni, R. N., Kahn, C. R., de Vargas, L. M., and Berggren, P. O. (2001) Mol Cell 7(3), 559-570

34.Adams, T. E., Epa, V. C., Garrett, T. P., and Ward, C. W. (2000) Cell Mol Life Sci 57(7), 1050-1093

35.Nakae, J., Kido, Y., and Accili, D. (2001) Endocr Rev 22(6), 818-835.

36.Siddle, K., Soos, M. A., Field, C. E., and Nave, B. T. (1994) Horm Res 41 Suppl 2, 56-64; discussion 65

37.Pessin, J. E. (1993) Adv. Exp. Med. Biol. 343, 133-144

38.Shier, P., and Watt, V. M. (1989) J Biol Chem 264, 14605-14608

39.Nef, S., Verma-Kurvari, S., Merenmies, J., Vassalli, J. D., Efstratiadis, A., Accili, D., and Parada, L. F. (2003) Nature 426(6964), 291-295

40.Kenyon, C. (2001) Cell 105(2), 165-168.

41.Finch, C. E., and Ruvkun, G. (2001) Annu Rev Genomics Hum Genet 2, 435-462

42.Tatar, M., Kopelman, A., Epstein, D., Tu, M. P., Yin, C. M., and Garofalo, R. S. (2001) Science 292(5514), 107-110.

43.Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., and Partridge, L. (2001) Science 292(5514), 104-106.

44.White, M. F., and Yenush, L. (1998) Curr Top Microbiol Immunol 228, 179-208

45.Tamemoto, H., Kadowaki, T., Tobe, K., Yagi, T., Sakura, H., Hayakawa, T., Terauchi, Y., Ueki, K., Kaburagi, Y., Satoh, S., and et al. (1994) Nature 372(6502), 182-186.

46.Araki, E., Lipes, M. A., Patti, M. E., Bruning, J. C., Haag, B., 3rd, Johnson, R. S., and Kahn, C. R. (1994) Nature 372(6502), 186-190.

47.Tamemoto, H., Tobe, K., Yamauchi, T., Terauchi, Y., Kaburagi, Y., and Kadowaki, T. (1997) Ann N Y Acad Sci 827, 85-93.

48.Withers, D. J., Gutierrez, J. S., Towery, H., Burks, D. J., Ren, J. M., Previs, S., Zhang, Y., Bernal, D., Pons, S., Shulman, G. I., Bonner-Weir, S., and White, M. F. (1998) Nature 391(6670), 900-904.

49.Kido, Y., Burks, D. J., Withers, D., Bruning, J. C., Kahn, C. R., White, M. F., and Accili, D. (2000) J Clin Invest 105(2), 199-205

50.Park, S., Dong, X., Fisher, T. L., Dunn, S., Omer, A. K., Weir, G., and White, M. F. (2006) J Biol Chem 281(2), 1159-1168

51.Fantin, V. R., Wang, Q., Lienhard, G. E., and Keller, S. R. (2000) Am J Physiol Endocrinol Metab 278(1), E127-133.

52.Tsuruzoe, K., Emkey, R., Kriauciunas, K. M., Ueki, K., and Kahn, C. R. (2001) Mol Cell Biol 21(1), 26-38.

53.Jackson, C. (2006) Nature 444(7121), 833-834

54.Hafner, M., Schmitz, A., Grune, I., Srivatsan, S. G., Paul, B., Kolanus, W., Quast, T., Kremmer, E., Bauer, I., and Famulok, M. (2006) Nature 444(7121), 941-944

55.Fuss, B., Becker, T., Zinke, I., and Hoch, M. (2006) Nature 444(7121), 945-948

56.Avruch, J. (1998) Mol Cell Biochem 182(1-2), 31-48

57.Czech, M. P., and Corvera, S. (1999) J Biol Chem 274(4), 1865-1868

58.Farese, R. V. (2001) Exp Biol Med (Maywood) 226(4), 283-295

59.Shepherd, P. R., Withers, D. J., and Siddle, K. (1998) Biochem J 333 ( Pt 3), 471-490

60.Ueki, K., Yamamoto-Honda, R., Kaburagi, Y., Yamauchi, T., Tobe, K., Burgering, B. M., Coffer, P. J., Komuro, I., Akanuma, Y., Yazaki, Y., and Kadowaki, T. (1998) J Biol Chem 273(9), 5315-5322

61.Cheatham, B., Vlahos, C. J., Cheatham, L., Wang, L., Blenis, J., and Kahn, C. R. (1994) Mol Cell Biol 14(7), 4902-4911

62.Clarke, J. F., Young, P. W., Yonezawa, K., Kasuga, M., and Holman, G. D. (1994) Biochem J 300 ( Pt 3), 631-635

63.Kanai, F., Ito, K., Todaka, M., Hayashi, H., Kamohara, S., Ishii, K., Okada, T., Hazeki, O., Ui, M., and Ebina, Y. (1993) Biochem Biophys Res Commun 195(2), 762-768

64.Okada, T., Sakuma, L., Fukui, Y., Hazeki, O., and Ui, M. (1994) J Biol Chem 269(5), 3563-3567

65.Katagiri, H., Asano, T., Ishihara, H., Inukai, K., Shibasaki, Y., Kikuchi, M., Yazaki, Y., and Oka, Y. (1996) J Biol Chem 271(29), 16987-16990

66.Martin, S. S., Haruta, T., Morris, A. J., Klippel, A., Williams, L. T., and Olefsky, J. M. (1996) J Biol Chem 271(30), 17605-17608

67.Calera, M. R., Martinez, C., Liu, H., Jack, A. K., Birnbaum, M. J., and Pilch, P. F. (1998) J Biol Chem 273(13), 7201-7204

68.Kohn, A. D., Summers, S. A., Birnbaum, M. J., and Roth, R. A. (1996) J Biol Chem 271(49), 31372-31378

69.Sakaue, H., Ogawa, W., Takata, M., Kuroda, S., Kotani, K., Matsumoto, M., Sakaue, M., Nishio, S., Ueno, H., and Kasuga, M. (1997) Mol Endocrinol 11(10), 1552-1562

70.Sharma, P. M., Egawa, K., Huang, Y., Martin, J. L., Huvar, I., Boss, G. R., and Olefsky, J. M. (1998) J Biol Chem 273(29), 18528-18537

71.Hajduch, E., Litherland, G. J., and Hundal, H. S. (2001) FEBS Lett 492(3), 199-203

72.Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., 3rd, Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., and Birnbaum, M. J. (2001) Science 292(5522), 1728-1731.

73.Cho, H., Thorvaldsen, J. L., Chu, Q., Feng, F., and Birnbaum, M. J. (2001) J Biol Chem 276(42), 38349-38352

74.Shulman, G. I. (2000) J Clin Invest 106(2), 171-176.

75.Baumann, C. A., Ribon, V., Kanzaki, M., Thurmond, D. C., Mora, S., Shigematsu, S., Bickel, P. E., Pessin, J. E., and Saltiel, A. R. (2000) Nature 407(6801), 202-207.

76.Ribon, V., Printen, J. A., Hoffman, N. G., Kay, B. K., and Saltiel, A. R. (1998) Mol Cell Biol 18(2), 872-879.

77.Chiang, S. H., Baumann, C. A., Kanzaki, M., Thurmond, D. C., Watson, R. T., Neudauer, C. L., Macara, I. G., Pessin, J. E., and Saltiel, A. R. (2001) Nature 410(6831), 944-948.

78.Stenbit, A. E., Tsao, T. S., Li, J., Burcelin, R., Geenen, D. L., Factor, S. M., Houseknecht, K., Katz, E. B., and Charron, M. J. (1997) Nat Med 3(10), 1096-1101.

79.Katz, E. B., Stenbit, A. E., Hatton, K., DePinho, R., and Charron, M. J. (1995) Nature 377(6545), 151-155.

80.Zisman, A., Peroni, O. D., Abel, E. D., Michael, M. D., Mauvais-Jarvis, F., Lowell, B. B., Wojtaszewski, J. F., Hirshman, M. F., Virkamaki, A., Goodyear, L. J., Kahn, C. R., and Kahn, B. B. (2000) Nat Med 6(8), 924-928.

81.Abel, E. D., Peroni, O., Kim, J. K., Kim, Y. B., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., and Kahn, B. B. (2001) Nature 409(6821), 729-733.

82.Elchebly, M., Payette, P., Michaliszyn, E., Cromlish, W., Collins, S., Loy, A. L., Normandin, D., Cheng, A., Himms-Hagen, J., Chan, C. C., Ramachandran, C., Gresser, M. J., Tremblay, M. L., and Kennedy, B. P. (1999) Science 283(5407), 1544-1548

83.Klaman, L. D., Boss, O., Peroni, O. D., Kim, J. K., Martino, J. L., Zabolotny, J. M., Moghal, N., Lubkin, M., Kim, Y. B., Sharpe, A. H., Stricker-Krongrad, A., Shulman, G. I., Neel, B. G., and Kahn, B. B. (2000) Mol Cell Biol 20(15), 5479-5489

84.Huyer, G., Liu, S., Kelly, J., Moffat, J., Payette, P., Kennedy, B., Tsaprailis, G., Gresser, M. J., and Ramachandran, C. (1997) J Biol Chem 272(2), 843-851

85.Goldfine, A. B., Simonson, D. C., Folli, F., Patti, M. E., and Kahn, C. R. (1995) Mol Cell Biochem 153(1-2), 217-231

86.Boden, G., Chen, X., Ruiz, J., van Rossum, G. D., and Turco, S. (1996) Metabolism 45(9), 1130-1135.

87.Halberstam, M., Cohen, N., Shlimovich, P., Rossetti, L., and Shamoon, H. (1996) Diabetes 45(5), 659-666.

88.Lazar, D. F., and Saltiel, A. R. (2006) Nat Rev Drug Discov 5(4), 333-342

89.Ali, I. U., Schriml, L. M., and Dean, M. (1999) J Natl Cancer Inst 91(22), 1922-1932

90.Nakashima, N., Sharma, P. M., Imamura, T., Bookstein, R., and Olefsky, J. M. (2000) J Biol Chem 275(17), 12889-12895.

91.Ono, H., Katagiri, H., Funaki, M., Anai, M., Inukai, K., Fukushima, Y., Sakoda, H., Ogihara, T., Onishi, Y., Fujishiro, M., Kikuchi, M., Oka, Y., and Asano, T. (2001) Mol Endocrinol 15(8), 1411-1422.

92.Butler, M., McKay, R. A., Popoff, I. J., Gaarde, W. A., Witchell, D., Murray, S. F., Dean, N. M., Bhanot, S., and Monia, B. P. (2002) Diabetes 51(4), 1028-1034

93.Blero, D., De Smedt, F., Pesesse, X., Paternotte, N., Moreau, C., Payrastre, B., and Erneux, C. (2001) Biochem Biophys Res Commun 282(3), 839-843.

94.Clement, S., Krause, U., Desmedt, F., Tanti, J. F., Behrends, J., Pesesse, X., Sasaki, T., Penninger, J., Doherty, M., Malaisse, W., Dumont, J. E., Le Marchand-Brustel, Y., Erneux, C., Hue, L., and Schurmans, S. (2001) Nature 409(6816), 92-97.

95.Sleeman, M. W., Wortley, K. E., Lai, K. M., Gowen, L. C., Kintner, J., Kline, W. O., Garcia, K., Stitt, T. N., Yancopoulos, G. D., Wiegand, S. J., and Glass, D. J. (2005) Nat Med 11(2), 199-205

96.Howard, J. K., and Flier, J. S. (2006) Trends Endocrinol Metab 17(9), 365-371

97.Kitamura, T., Kahn, C. R., and Accili, D. (2003) Annu Rev Physiol 65, 313-332

98.Bruning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Horsch, D., Accili, D., Goodyear, L. J., and Kahn, C. R. (1998) Mol Cell 2(5), 559-569

99.Guerra, C., Navarro, P., Valverde, A. M., Arribas, M., Bruning, J., Kozak, L. P., Kahn, C. R., and Benito, M. (2001) J Clin Invest 108(8), 1205-1213

100.Kulkarni, R. N., Winnay, J. N., Daniels, M., Bruning, J. C., Flier, S. N., Hanahan, D., and Kahn, C. R. (1999) J Clin Invest 104(12), R69-75

101.Kulkarni, R. N., Bruning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., and Kahn, C. R. (1999) Cell 96(3), 329-339

102.Lauro, D., Kido, Y., Castle, A. L., Zarnowski, M. J., Hayashi, H., Ebina, Y., and Accili, D. (1998) Nat Genet 20(3), 294-298

103.Mauvais-Jarvis, F., Virkamaki, A., Michael, M. D., Winnay, J. N., Zisman, A., Kulkarni, R. N., and Kahn, C. R. (2000) Diabetes 49(12), 2126-2134

104.Mauvais-Jarvis, F., and Kahn, C. R. (2000) Diabetes Metab 26(6), 433-448

105.DeFronzo, R. A., Bonadonna, R. C., and Ferannini, E. (1992) Diab Care 15, 318-368

106.Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., and Kahn, C. R. (2000) Mol Cell 6(1), 87-97.

107.Bergman, R. N., and Ader, M. (2000) Trends Endocrinol Metab 11(9), 351-356.

108.Dajani, R., Fraser, E., Roe, S. M., Young, N., Good, V., Dale, T. C., and Pearl, L. H. (2001) Cell 105(6), 721-732

109.Frame, S., Cohen, P., and Biondi, R. M. (2001) Mol Cell 7(6), 1321-1327

110.Harwood, A. J. (2001) Cell 105(7), 821-824

111.Ryves, W. J., and Harwood, A. J. (2001) Biochem Biophys Res Commun 280(3), 720-725

112.Newgard, C. B., Brady, M. J., O'Doherty, R. M., and Saltiel, A. R. (2000) Diabetes 49(12), 1967-1977.

113.Pilkis, S., and Granner, D. (1992) Annu. Rev. Physiol. 54, 885-909

114.Nakae, J., Park, B. C., and Accili, D. (1999) J Biol Chem 274(23), 15982-15985.

115.Scheimann, A. O., Durham, S. K., Suwanichkul, A., Snuggs, M. B., and Powell, D. R. (2001) Horm Metab Res 33(11), 631-638.

116.Barthel, A., Schmoll, D., Kruger, K. D., Bahrenberg, G., Walther, R., Roth, R. A., and Joost, H. G. (2001) Biochem Biophys Res Commun 285(4), 897-902.

117.Yeagley, D., Guo, S., Unterman, T., and Quinn, P. G. (2001) J Biol Chem 276(36), 33705-33710.

118.Lochhead, P. A., Coghlan, M., Rice, S. Q., and Sutherland, C. (2001) Diabetes 50(5), 937-946.

119.Rena, G., Prescott, A. R., Guo, S., Cohen, P., and Unterman, T. G. (2001) Biochem J 354(Pt 3), 605-612.

120.Cahill, C. M., Tzivion, G., Nasrin, N., Ogg, S., Dore, J., Ruvkun, G., and Alexander-Bridges, M. (2001) J Biol Chem 276(16), 13402-13410.

121.Tomizawa, M., Kumar, A., Perrot, V., Nakae, J., Accili, D., Rechler, M. M., and Kumaro, A. (2000) J Biol Chem 275(10), 7289-7295.

122.Tang, E. D., Nunez, G., Barr, F. G., and Guan, K. L. (1999) J Biol Chem 274(24), 16741-16746.

123.Guo, S., Rena, G., Cichy, S., He, X., Cohen, P., and Unterman, T. (1999) J Biol Chem 274(24), 17184-17192.

124.Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., Spiegelman, B., and Montminy, M. (2001) Nature 413(6852), 179-183.

125.Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., Newgard, C. B., and Spiegelman, B. M. (2001) Nature 413(6852), 131-138.

126.Brown, M. S., and Goldstein, J. L. (1998) Nutr Rev 56(2 Pt 2), S1-3; discussion S54-75.

127.Foretz, M., Guichard, C., Ferre, P., and Foufelle, F. (1999) Proc Natl Acad Sci U S A 96(22), 12737-12742.

128.Foretz, M., Pacot, C., Dugail, I., Lemarchand, P., Guichard, C., Le Liepvre, X., Berthelier-Lubrano, C., Spiegelman, B., Kim, J. B., Ferre, P., and Foufelle, F. (1999) Mol Cell Biol 19(5), 3760-3768.

129.Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., and Brown, M. S. (1998) Genes Dev 12(20), 3182-3194.

130.Shimomura, I., Bashmakov, Y., and Horton, J. D. (1999) J Biol Chem 274(42), 30028-30032.

131.Shimomura, I., Bashmakov, Y., Ikemoto, S., Horton, J. D., Brown, M. S., and Goldstein, J. L. (1999) Proc Natl Acad Sci U S A 96(24), 13656-13661.

132.Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y., Brown, M. S., and Goldstein, J. L. (2000) Mol Cell 6(1), 77-86.

133.Botion, L. M., and Green, A. (1999) Diabetes 48(9), 1691-1697.

134.Rosenstock, M., Greenberg, A. S., and Rudich, A. (2001) Diabetologia 44(1), 55-62.

135.Sztalryd, C., Komaromy, M. C., and Kraemer, F. B. (1995) J Clin Invest 95(6), 2652-2661.

136.Kahn, B. B., and Flier, J. S. (2000) J Clin Invest 106(4), 473-481

137.Spiegelman, B. M., and Flier, J. S. (2001) Cell 104(4), 531-543.

138.Kahn, S. E., Hull, R. L., and Utzschneider, K. M. (2006) Nature 444(7121), 840-846

139.Maddux, B. A., Sbraccia, P., Reaven, G. M., Moller, D. E., and Goldfine, I. D. (1993) J Clin Endocrinol Metab 77, 73-79

140.Zimmet, P., Alberti, K. G., and Shaw, J. (2001) Nature 414(6865), 782-787.

141.Reaven, G. M. (1988) Diabetes 37, 1595-1607

142.McGarry, J. D. (1992) Science 258, 766-770

143.Boden, G., Chen, X., Ruiz, J., White, J. V., and Rossetti, L. (1994) J Clin Invest 93(6), 2438-2446.

144.Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., Petersen, K. F., and Shulman, G. I. (1999) J Clin Invest 103(2), 253-259.

145.Massillon, D., Barzilai, N., Hawkins, M., Prus-Wertheimer, D., and Rossetti, L. (1997) Diabetes 46(1), 153-157.

146.Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Roden, M., and Shulman, G. I. (1999) Diabetologia 42(1), 113-116.

147.Perseghin, G., Scifo, P., De Cobelli, F., Pagliato, E., Battezzati, A., Arcelloni, C., Vanzulli, A., Testolin, G., Pozza, G., Del Maschio, A., and Luzi, L. (1999) Diabetes 48(8), 1600-1606.

148.Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D., and Haring, H. U. (1999) Diabetes 48(5), 1113-1119.

149.Ruderman, N. B., Saha, A. K., Vavvas, D., and Witters, L. A. (1999) Am J Physiol 276(1 Pt 1), E1-E18.

150.Virkamaki, A., Korsheninnikova, E., Seppala-Lindroos, A., Vehkavaara, S., Goto, T., Halavaara, J., Hakkinen, A. M., and Yki-Jarvinen, H. (2001) Diabetes 50(10), 2337-2343.

151.Greco, A. V., Mingrone, G., Giancaterini, A., Manco, M., Morroni, M., Cinti, S., Granzotto, M., Vettor, R., Camastra, S., and Ferrannini, E. (2002) Diabetes 51(1), 144-151.

152.Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., Breslow, J. L., and Shulman, G. I. (2001) Proc Natl Acad Sci U S A 98(13), 7522-7527.

153.De Fea, K., and Roth, R. A. (1997) J Biol Chem 272(50), 31400-31406

154.De Fea, K., and Roth, R. A. (1997) Biochemistry 36(42), 12939-12947

155.Delahaye, L., Mothe-Satney, I., Myers, M. G., White, M. F., and Van Obberghen, E. (1998) Endocrinology 139(12), 4911-4919

156.Qiao, L. Y., Goldberg, J. L., Russell, J. C., and Sun, X. J. (1999) J Biol Chem 274(15), 10625-10632

157.Aguirre, V., Werner, E. D., Giraud, J., Lee, Y. H., Shoelson, S. E., and White, M. F. (2002) J Biol Chem 277(2), 1531-1537

158.Ravichandran, L. V., Esposito, D. L., Chen, J., and Quon, M. J. (2001) J Biol Chem 276(5), 3543-3549

159.Rui, L., Aguirre, V., Kim, J. K., Shulman, G. I., Lee, A., Corbould, A., Dunaif, A., and White, M. F. (2001) J Clin Invest 107(2), 181-189

160.Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z. W., Karin, M., and Shoelson, S. E. (2001) Science 293(5535), 1673-1677

161.Kim, J. K., Kim, Y. J., Fillmore, J. J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z. W., Karin, M., Perret, P., Shoelson, S. E., and Shulman, G. I. (2001) J Clin Invest 108(3), 437-446

162.Maddux, B. A., Sbraccia, P., Kumakura, S., Sasson, S., Youngren, J., Fisher, A., Spencer, S., Grupe, A., Henzel, W., Stewart, T. A., Reaven, G. M., and Goldfine, I. D. (1995) Nature 373, 448-451

163.Frittitta, L., Youngren, J. F., Sbraccia, P., D'Adamo, M., Buongiorno, A., Vigneri, R., Goldfine, I. D., and Trischitta, V. (1997) Diabetologia 40(3), 282-289.

164.Maddux, B. A., and Goldfine, I. D. (2000) Diabetes 49(1), 13-19.

165.Goldfine, I. D., Maddux, B. A., Youngren, J. F., Trischitta, V., and Frittitta, L. (1999) Ann N Y Acad Sci 892, 204-222.

166.Hotamisligil, G. S., Shargill, N. S., and Spiegelman, B. M. (1993) Science 259(5091), 87-91

167.Hotamisligil, G. S. (2006) Nature 444(7121), 860-867

168.Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., and Flier, J. S. (2006) J Clin Invest 116(11), 3015-3025

169.Wellen, K. E., Fucho, R., Gregor, M. F., Furuhashi, M., Morgan, C., Lindstad, T., Vaillancourt, E., Gorgun, C. Z., Saatcioglu, F., and Hotamisligil, G. S. (2007) Cell 129(3), 537-548

170.Hotamisligil, G. S., Shargill, N. S., and Spiegelman, B. M. (1993) Science 259, 87-90

171.Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., and Spiegelman, B. M. (1995) J Clin Invest 95, 2409-2415

172.Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., and Simsolo, R. B. (1995) J Clin Invest 95(5), 2111-2119.

173.Saghizadeh, M., Ong, J. M., Garvey, W. T., Henry, R. R., and Kern, P. A. (1996) J Clin Invest 97(4), 1111-1116.

174.Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., and Spiegelman, B. M. (1996) Science 271, 665-668

175.Feinstein, R., Kanety, H., Papa, M. Z., Lunenfeld, B., and Karasik, A. (1993) J Biol Chem 268, 26055-26058

176.Stephens, J. M., Lee, J., and Pilch, P. F. (1997) J Biol Chem 272(2), 971-976.

177.Zhang, B., Berger, J., Hu, E., Szalkowski, D., White-Carrington, S., Spiegelman, B. M., and Moller, D. E. (1996) Mol Endocrinol 10(11), 1457-1466

178.Olefsky, J. M. (2000) J Clin Invest 106(4), 467-472.

179.Szalkowski, D., White-Carrington, S., Berger, J., and Zhang, B. (1995) Endocrinol 136, 1474-1481

180.Souza, S. C., Yamamoto, M. T., Franciosa, M. D., Lien, P., and Greenberg, A. S. (1998) Diabetes 47(4), 691-695.

181.Miles, P. D., Romeo, O. M., Higo, K., Cohen, A., Rafaat, K., and Olefsky, J. M. (1997) Diabetes 46(11), 1678-1683.

182.Friedman, J. M., and Halaas, J. L. (1998) Nature 395(6704), 763-770.

183.Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., and Friedman, J. M. (1995) Science 269(5223), 543-546.

184.Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., and Goldstein, J. L. (1999) Nature 401(6748), 73-76.

185.Minokoshi, Y., Kim, Y. B., Peroni, O. D., Fryer, L. G., Muller, C., Carling, D., and Kahn, B. B. (2002) Nature 415(6869), 339-343.

186.Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., Gorden, P., and Garg, A. (2002) N Engl J Med 346(8), 570-578.

187.Scherer, P. E., Williams, S., Fogliano, M., Baldini, G., and Lodish, H. F. (1995) J Biol Chem 270(45), 26746-26749

188.Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., Kuriyama, H., Nishida, M., Yamashita, S., Okubo, K., Matsubara, K., Muraguchi, M., Ohmoto, Y., Funahashi, T., and Matsuzawa, Y. (1999) Biochem Biophys Res Commun 257(1), 79-83

189.Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., and Tataranni, P. A. (2001) J Clin Endocrinol Metab 86(5), 1930-1935

190.Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., Kuriyama, H., Hotta, K., Nakamura, T., Shimomura, I., and Matsuzawa, Y. (2001) Diabetes 50(9), 2094-2099

191.Combs, T. P., Wagner, J. A., Berger, J., Debber, T., Wang, W.-J., Zhang, B. B., Tanen, M., Berg, A. H., O'Rahilly, S., Savage, D. B., Chatterjee, K., Weiss, S., Larson, P. J., Gottesdiener, K. M. r., Gertz, B. J., Charron, M. J. n., Scherer , P. E., and Moller, D. E. (2002) Endocrinology 143(3), 998-1007

192.Berg, A., Combs, T., Du, X., Brownlee, M., and PE, S. (2001) Nature Medicine 7, 947-953

193.Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., Ezaki, O., Akanuma, Y., Gavrilova, O., Vinson, C., Reitman, M. L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S., Tomita, M., Froguel, P., and Kadowaki, T. (2001) Nat Med 7(8), 941-946

194.Fruebis, J., Tsao, T.-S., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F., Bihain, B., and Lodish, H. (2001) Proc. Natl. Acad. Sci. USA 98(4), 2005-2010

195.Wang, C., Mao, X., Wang, L., Liu, M., Wetzel, M. D., Guan, K. L., Dong, L. Q., and Liu, F. (2007) J Biol Chem

196.Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., and Lazar, M. A. (2001) Nature 409(6818), 307-312.

197.Steppan, C. M., Brown, E. J., Wright, C. M., Bhat, S., Banerjee, R. R., Dai, C. Y., Enders, G. H., Silberg, D. G., Wen, X., Wu, G. D., and Lazar, M. A. (2001) Proc Natl Acad Sci U S A 98(2), 502-506.

198.Way, J. M., Gorgun, C. Z., Tong, Q., Uysal, K. T., Brown, K. K., Harrington, W. W., Oliver, W. R., Jr., Willson, T. M., Kliewer, S. A., and Hotamisligil, G. S. (2001) J Biol Chem 276(28), 25651-25653.

199.McTernan, C. L., McTernan, P. G., Harte, A. L., Levick, P. L., Barnett, A. H., and Kumar, S. (2002) Lancet 359(9300), 46-47.

200.Nagaev, I., and Smith, U. (2001) Biochem Biophys Res Commun 285(2), 561-564.

201.Savage, D. B., Sewter, C. P., Klenk, E. S., Segal, D. G., Vidal-Puig, A., Considine, R. V., and O'Rahilly, S. (2001) Diabetes 50(10), 2199-2202.

202.Janke, J., Engeli, S., Gorzelniak, K., Luft, F. C., and Sharma, A. M. (2002) Obes Res 10(1), 1-5.

203.Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., and Kahn, B. B. (2005) Nature 436(7049), 356-362

204.Gavi, S., Stuart, L. M., Kelly, P., Melendez, M. M., Mynarcik, D. C., Gelato, M. C., and McNurlan, M. A. (2007) J Clin Endocrinol Metab 92(5), 1886-1890

205.Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., Watanabe, E., Takagi, T., Akiyoshi, M., Ohtsubo, T., Kihara, S., Yamashita, S., Makishima, M., Funahashi, T., Yamanaka, S., Hiramatsu, R., Matsuzawa, Y., and Shimomura, I. (2005) Science 307(5708), 426-430

206.Yang, R. Z., Lee, M. J., Hu, H., Pray, J., Wu, H. B., Hansen, B. C., Shuldiner, A. R., Fried, S. K., McLenithan, J. C., and Gong, D. W. (2006) Am J Physiol Endocrinol Metab 290(6), E1253-1261

207.de Souza Batista, C. M., Yang, R. Z., Lee, M. J., Glynn, N. M., Yu, D. Z., Pray, J., Ndubuizu, K., Patil, S., Schwartz, A., Kligman, M., Fried, S. K., Gong, D. W., Shuldiner, A. R., Pollin, T. I., and McLenithan, J. C. (2007) Diabetes, [Epub ahead of print]

208.Zhang, B., Salituro, G., Szalkowski, D., Li, Z., Zhang, Y., Royo, I., Vilella, D., Diez, M. T., Pelaez, F., Ruby, C., Kendall, R. L., Mao, X., Griffin, P., Calaycay, J., Zierath, J. R., Heck, J. V., Smith, R. G., and Moller, D. E. (1999) Science 284(5416), 974-977

209.Qureshi, S. A., Ding, V., Li, Z., Szalkowski, D., Biazzo-Ashnault, D., Xie, D., Saperstein, R., Brady, E., Huskey, S., Shen, X., Liu, K., Xu, L., Salituro, G. M., Heck, J. V., Moller, D. E., Jones, A. B., and Zhang, B. B. (2000) J Biol Chem 275, 36590-36595

210.Manchem, V. P., Goldfine, I. D., Kohanski, R. A., Cristobal, C. P., Lum, R. T., Schow, S. R., Shi, S., Spevak, W. R., Laborde, E., Toavs, D. K., Villar, H. O., Wick, M. M., and Kozlowski, M. R. (2001) Diabetes 50(4), 824-830

211.Li, M., Youngren, J. F., Manchem, V. P., Kozlowski, M., Zhang, B. B., Maddux, B. A., and Goldfine, I. D. (2001) Diabetes 50(10), 2323-2328