Table of Contents

Introduction

Mediators of insulin signal transduction pathway

Insulin receptor

IRS proteins

PI3 kinase/Akt pathways

GLUT4 translocation

Negative regulators of insulin signal transduction pathway

PTP1B

SHIP2 and PTEN

SOCS family of proteins

Insights into insulin resistance from knockout mouse models

Regulation of Glucose and lipid metabolism

Glycogen synthesis and gluconeogenesis

Lipid synthesis and degradation

Modulation of insulin signaling

Obesity and insulin resistance

Inflammation and insulin resistance

Adipose-secreted proteins

Insulin receptor activators

Perspectives