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	INTRODUCTION
	GENERAL MECHANISM OF CENTRAL OVULATORY DYSFUNCTION
	FUNCTIONAL HYPOTHALAMIC AMENORRHEA
	MODULATION OF GNRH SECRETION BY OPIOIDERGIC, DOPAMINERGIC, AND EXCITATORY AMINO ACIDS
	LINK BETWEEN STRESS AND REPRODUCTIVE DYSFUNCTION
	CLINICAL MANAGEMENT OF FUNCTIONAL HYPOTHALAMIC AMENORRHEA
	BULIMIA AND ANOREXIA NERVOSA
	EXERCISE-INDUCED HYPOTHALAMIC AMENORRHEA
	OTHER CAUSES OF HYPOGONADO- TROPINISM
	Isolated Gonadotropin Deficiency (IGD)
	POSTPARTUM PITUITARY NECROSIS (SHEEHAN SYNDROME)
	POST-TRAUMATIC HYPOPITUITARISM
	PITUITARY APOPLEXY
	POSTRADIATION- INDUCED HYPOPITUITARISM
	SUMMARY