Table of Contents

Age Distribution.

Natural History.

Diagnosis.

Biochemical Studies.

Localization Studies.

Scintigraphic Detection with MIBG or Octreotide Scanning.

Carcinoid Syndrome.

Non Insulinoma Pancreatogenous Hypoglycemic Syndrome (NIPHS)

Flushing.

C-Cell Hyperplasia Syndrome

Diarrhea.

Carcinoid Heart Disease

Carcinoid Bone metastasis - Osteolytic and Osteoblastic

What makes bone a favorable site for metastases?

Screening:

Treatment for Bone Metastases (BM):

New therapeutic targets

Prognosis.

Therapy.

Responses to Octreotide.

Flushing

Diarrhea.

Effects of octreotide on pulmonary function.

Effects of octreotide on myopathy.

Biochemical responses.

Responses of tumor growth and metastases to octreotide.

Internal Radiotherapy Delivered by Meta Iodo Benzyl Guanidine (MIBG).

Dearterialization.

Radiation Therapy.

Radiochemoembolisation.

Chemotherapy.

Tyrosine Kinase (TK) receptor and TK inhibitors in Carcinoid:

Role of mammalian target of rapamycin (mTOR) pathway in Neuroendocrine Tumors:

Regulation of cell proliferation and angiogenesis through various growth factors:

Biologic Therapy.

Evaluation

Adjuvant Therapy.

Summary and Conclusion