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TABLE OF CONTENTS

  • INTRODUCTION
  • AETIOLOGY OF HYPOPITUITARISM
  • CONGENITAL
  • HESX-1 Mutations
  • PIT-1 Defect
  • PROP-1 Defect
  • KAL
  • DAX-1
  • GH1 Gene Mutations
  • SOX 2
  • TUMORS
  • Pituitary Adenoma
  • Craniopharyngiomas
  • Peripituitary tumours
  • VASCULAR
  • INFLAMMATORY LESIONS
  • INFECTIONS
  • RADIATION THERAPY
  • TRAUMATIC BRAIN INJURY
  • EMPTY SELLA SYNDROME
  • CLINICAL MANIFESTATION OF HYPOPITUITARISM
  • Growth Hormone Deficiency
  • Adrenocorticotrophic Hormone Deficiency
  • Gonadotrophin Deficiency
  • Thyroid Stimulating Hormone Deficiency
  • Prolactin
  • Antidiuretic Hormone Deficiency
  • INVESTIGATION OF SUSPECTED HYPOPITUITARISM
  • BASELINE INVESTIGATIONS
  • DYNAMIC TESTING
  • Hypothalamo-pituitary-adrenal axis
  • Growth Hormone
  • Pituitary-Thyroid axis
  • Pituitary-Gonadal axis
  • Posterior Pituitary Function
  • IMAGING THE PITUITARY
  • MANAGEMENT OF HYPOPITUITARISM
  • Hypoadrenalism
  • Secondary Hypothyroidism
  • Gonadotrophin Deficiency
  • Women
  • Men
  • Monitoring testosterone replacement
  • Diabetes Insipidus
  • Growth Hormone Deficiency