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TABLE OF CONTENTS

  • INTRODUCTION
  • Pineal Structure
  • MELATONIN SYNTHESIS AND METABOLISM
  • Control of Melatonin Synthesis: A Darkness Hormone
  • Daylength Dependence of Melatonin Secretion
  • Synchronisation of the Melatonin Rhythm to the 24h Day
  • PHYSIOLOGICAL FUNCTIONS OF MELATONIN IN MAMMALS
  • Melatonin Secretion as a Function of Daylength: a Seasonal Time Cue
  • Role of the Pineal Gland and Melatonin in Circadian Rhythms
  • EFFECTS OF TIMED ADMINISTRATION OF MELATONIN IN MAMMALS
  • In vivo effects
  • In Vitro Phase Shifts
  • Retinal Rhythms
  • Miscellaneous
  • HUMAN PINEAL PHYSIOLOGY AND PATHOLOGY
  • Human Melatonin Production
  • Melatonin and Core Body Temperature
  • Melatonin and Sleep
  • Melatonin during Development, Puberty, Menstrual cycle and Aging
  • PATHOLOGY
  • Post-Mortem observations: Pineal Hyper- and Hypoplasia
  • Pineal Tumors
  • Other Solid Tumors
  • Psychiatry
  • Melatonin and metabolism
  • Miscellaneous
  • EFFECTS OF MELATONIN IN HUMANS
  • Sleep and Circadian Rhythms
  • Reproductive axis
  • Miscellaneous
  • THERAPEUTIC USE OF MELATONIN
  • Jet Lag and Shift Work
  • Sleep Disorder in the Elderly
  • Delayed Sleep Phase Insomnia
  • Cancer
  • MECHANISM OF ACTION OF MELATONIN
  • Target Sites
  • Melatonin Receptors
  • Melatonin Antagonists and Agonists
  • Effects on Clock Genes