Table of Contents

Introduction

Pathophysiology , Aetiology & Epidemiology

ACTH-dependent Cushing's syndrome.

Cushing's Disease

Ectopic ACTH syndrome & ectopic CRH tumors

ACTH-independent Cushing Syndrome

Pseudo Cushing's syndrome

Clinical & Laboratory Features

Biochemical confirmation of Cushing's syndrome

Urinary free cortisol

Low-dose dexamethasone suppression test

The dexamethasone-CRH test

The Differential Diagnosis of Cushing's syndrome

Investigating ACTH-independent Cushing's syndrome

Identifying the source in ACTH-dependent Cushing's syndrome

Invasive testing

Non-invasive tests

Imaging

Pituitary

Ectopic tumours

Investigative strategy for the diagnosis and differential diagnosis of

Treatment of Cushing’s syndrome

Surgical Management

Postoperative Evaluation and Management

Adrenalectomy

Surgery for the ectopic ACTH syndrome

Radiotherapy

Medical Management

Cushing's syndrome in specific groups

Chronic Renal Failure

Paediatric Cushing’s Syndrome

Cushing’s Syndrome in Pregnancy

Prognosis