Table of Contents

INTRODUCTION

GROWTH DISORDERS

DIAGNOSIS

Growth charts:

Radiologic evaluation:

Biochemical evaluation of GH deficiency:

Summary of diagnosis of GH deficiency:

Key elements that may indicate GH deficiency are:

TREATMENT

Monitoring GH Treatment

The Safety of GH Treatment

Recombinant human IGF-1 (rhIGF-1) and rhIGF-1/IGFBP-3 complex

MULTIPLE PITUITARY HORMONE DEFICIENCY (MPHD)

ISOLATED GH DEFICIENCY (IGHD)

HYPOTHALAMIC GH DEFICIENCY

Synthesis and Secretion of GH

TIMING

Growth Hormone Releasing Hormone

Growth Hormone Releasing Hormone Receptor

Ghrelin

Ghrelin Receptor

Somatostatin

PITUITARY GH DEFICIENCY

Human Growth Hormone

PERIPHERAL GH RESISTANCE

Growth Hormone Receptor

Insulin-Like Growth Factor 1

Insulin-Like Growth Factor 1 Receptor (IGF1R)

Insulin-Like Growth Factor 2

Insulin-Like Growth Factor 2 Receptor

Insulin

Insulin Receptor

CONCLUSION

ACKNOWLEDGMENT