Craniopharyngiomas and adenomas are the most frequent lesions of the pituitary region in children and adolescents. While craniopharyngiomas are the most frequent cause of acquired hypopituitarism in children, pituitary adenomas are rare constituting less than 3% of supra-tentorial tumors. The most frequent tumor hystotypes are PRL-secreting and ACTH-secreting adenomas, while GH-, TSH-secreting and clinically nonfunctioning adenomas are very rare. The clinical presentation varies according to the tumor histotype, but stunted growth is a frequent sign of macroadenomas. Surgery is almost always the treatment of choice for both craniopharyngiomas and adenomas, with the exception of PRL-secreting adenomas which can be successfully managed using dopamine-agonists. Radiotherapy should be reserved to very aggressive tumors due to the very high incidence of subsequent hypopituitarism.