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TABLE OF CONTENTS

  • ETIOLOGIC CLASSIFICATION
  • Type 1 Diabetes
  • Type 2 Diabetes
  • Genetic Defects of ß-cell Function (Monogenic Diabetes)
  • Genetic Defects in Insulin Action
  • Endocrinopathies
  • Drug- or Chemical-induced Diabetes
  • Viral Infections
  • Uncommon forms of Immune-mediated Diabetes
  • NATURAL HISTORY OF HUMAN TYPE-1 DIABETES
  • a). Structure and Functions of The Pancreas
  • b). Metabolic Derangements of Type-1 Diabetes
  • c). Genetic Susceptibility of Type-1 Diabetes
  • d). Autoantigens and Autoantibodies in Type-1 Diabetes
  • e). Antigen Specific Cellular Immunity in Type-1 Diabetes
  • Pathogenesis of Type-1 Diabetes
  • The inductive event in Type-1 Diabetes
  • i. Molecular Mimicry
  • ii. Superantigens
  • DEFICIENCIES IN IMMUNOREGULATION IN TYPE 1 DIABETES
  • ENVIRONMENTAL FACTORS in Type-1 Diabetes
  • ROLE OF DIET
  • SCREENING METHODS AND PREVENTION OF T1DM
  • T1DM Prevention Trials
  • TREATMENT OF TYPE 1 DIABETES
  • Clinical Management
  • Transplantation of the Pancreas
  • INSULIN RESISTANCE SYNDROME (IRS)
  • a). Natural history of Insulin resistance Syndrome
  • b). Underlying mechanisms of Insulin resistance
  • c). Treatment
  • TYPE-2 DIABETES
  • SUMMARY