1. Komatsu, M., T. Kondo, K. Yamauchi, N. Yokokawa, K. Ichikawa, M. Ishihara, T. Aizawa, T. Yamada, Y. Imai, K. Tanaka, and et al. 1988. Antipituitary antibodies in patients with the primary empty sella syndrome. J Clin Endocrinol Metab 67:p633.

2. Arulanantham, K., J. M. Dwyer, and M. Genel. 1979. Evidence for defective immunoregulation in the syndrome of familial candidiasis endocrinopathy. N Engl J Med 300:p164.

3. Wilkin, T. J. 1990. Receptor autoimmunity in endocrine disorders. N Engl J Med 323:p1318.

4. R. Wildin, S. Smyk-Pearson, A. Filipovich. 2002. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet 39:p537.

5. R. Bacchetta, L. Passerini, E. Gambineri, and et al. 2006. Defective regulatory and effector T cell functions in patients wit FOXP3 mutations. J Clin Invest 116:p1713.

6. Eisenbarth, G. S., P. W. Wilson, F. Ward, C. Buckley, and H. Lebovita. 1979. The polyglandular failure syndrome: disease inheritance, HLA type, and immune function. Ann Intern Med 91:p528.

7. I. Mackay, N. Leskovsek, N. Rose. 2008. Cell damage and autoimmunity: a critical appraisal. J Autoimmun 30:p5.

8. Y. Lee, Y. Rho, S. Choi, and et al. 2007. The PTPN22 C1858T functional polymorphism and autoimmune diseases – a meta-analysis. Rheumatology (Oxford) 46:p49.

9. N. Maclaren. 2009. Autoimmune polyglandular syndromes. Endocrinology, Fifth Edition Chapter 149.

10.A. Lleo, P. Invernizzi, I. Mackay, and et al. 2008. Etiopathogenesis of primary biliary cirrhosis. World J Gastroenterol 14:p3328.

11. Muir, A., D. A. Schatz, and N. K. Maclaren. 1995. Polyglandular failure syndromes. Saunders, W.B., Philadelphia.

12. Maclaren, N. K., and W. J. Riley. 1985. Thyroid, gastric, and adrenal autoimmunities associated with insulin-dependent diabetes mellitus. Diabetes Care 1:34.

13. Maclaren, N., and W. Riley. 1988. Polyglandular autoimmunity:Autoimmune diseases of the parathyroid and adrenal glands. Little Brown and Company, Boston.

14. Schatz, D., W. Winter, and N. MAclaren. 1990. Immunology of insulin dependent diabetes. CRC Press, Boca Raton.

15. Bottazzo, G. F., I. Todd, R. Mirakian, A. Belfiore, and R. Pujol-Borrell. 1986. Organ-specific autoimmunity: a 1986 overview. Immunol Rev 94:137.

16. A. Mangalam, G. Rajagopalan, V. Taneja, C. David. 2008. HLA class II transgenic mice mimic human inflammatory diseases. Adv Immunol 97:p65.

17. Addison, T. 1849. Anaemia-Disease of the suprarenal capsules. Lond Med Gaz 8:517.

18. Ogle, J. W. 1866. On disease of the brain as a result of diabetes mellitus. St George Hosp Rep 1:157.

19. Claude, H., and H. Gourgerot. 1908. Insufficience pluriglandulaire endocrinienne. J Physiol Pathol 10:469.

20. Parkinson, J. 1910. A cause of pernicious anaemia terminating in acute diabetes. Lancet 2:543.

21. Hashimoto, H. 1912. Zur Kenntnis der lymphomatosen veranderung der schilddruse (struma lymphomatosa). Acta Klim Chir 97:219.

22. Von Meyenburg, H. 1940. Uber "insulitis" bei diabetes. Schweizerische Medizinische Wochenschrift 21:554.

23. Schmidt, M. B. 1926. Eine biglandulare Erkrankung (Nebennieren und Schilddrusse) bei Morbus Addisonii. Verh Dtsch Ges Pathol 21:212.

24. Carpenter, C. C. J., N. Solomon, and S. G. e. a. Silverberg. 1964. A review of the literature and a report of fifteen new cases including ten instances of co-existent diabetes mellitus. Medicine (Baltimore) 43:153.

25. Roitt, I. M., D. Doniach, and P. N. e. a. Campbell. 1956. Autoantibodies in Hashimoto's disease (lymphadenoid goiter). Lancet 2:820.

26. Anderson, J. R., R. B. Goudie, K. Gray, and G. C. Timbury. 1957. Auto-antibodies in Addison's disease. Lancet 1:1123.

27. Blizzard, R. M., and M. Kyle. 1963. Studies of the adrenal antigens and antibodies in Addison's disease. J Clin Invest 42:1653.

28. Solomon, N., C. J. C. Carpenter, I. L. Bennett, and A. M. Harvey. 1965. Schmidt's syndrome (thyroid and adrenal insufficiency) and coexistent diabetes mellitus. Diabetes 14:300.

29. Irvine, W. J., B. F. Clarke, L. Scarth, D. R. Cullen, and L. J. Duncan. 1970. Thyroid and gastric autoimmunity in patients with diabetes mellitus. Lancet 2:163.

30. Karlsson, F. A., P. Burman, L. Loof, and S. Mardh. 1988. Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+,K+-adenosine triphosphatase of the stomach. J Clin Invest 81:475.

31. Song, Y. H., E. L. Connor, A. Muir, J. X. She, B. Zorovich, D. Derovanesian, and N. Maclaren. 1994. Autoantibody epitope mapping of the 21-hydroxylase antigen in autoimmune Addison's disease. J Clin Endocrinol Metab 78:1108.

32. Neufeld, M., N. Maclaren, and R. Blizzard. 1980. Autoimmune polyglandular syndromes. Pediatr Ann 9:p154

33. Nagamine, K., P. Peterson, H. S. Scott, J. Kudoh, S. Minoshima, M. Heino, K. J. Krohn, M. D. Lalioti, P. E. Mullis, S. E. Antonarakis, K. Kawasaki, S. Asakawa, F. Ito, and N. Shimizu. 1997. Positional cloning of the APECED gene. Nat Genet 17:p393.

34. Consortium, T. F.-G. A. 1997. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 17:399.

35. Peterson, P., and K. J. Krohn. 1994. Mapping of B cell epitopes on steroid 17 alpha-hydroxylase, an autoantigen in autoimmune polyglandular syndrome type I. Clin Exp Immunol 98:p104.

36. Peterson, P., R. Uibo, J. Peranen, and K. Krohn. 1997. Immunoprecipitation of steroidogenic enzyme autoantigens with autoimmune polyglandular syndrome type I (APS I) sera; further evidence for independent humoral immunity to P450c17 and P450c21. Clin Exp Immunol 107:p335.

37. Tanaka, H., M. S. Perez, M. Powell, J. F. Sanders, J. Sawicka, S. Chen, L. Prentice, T. Asawa, C. Betterle, M. Volpato, B. R. Smith, and J. Furmaniak. 1997. Steroid 21-hydroxylase autoantibodies: measurements with a new immunoprecipitation assay. J Clin Endocrinol Metab 82:p1440.

38. Uibo, R., E. Aavik, P. Peterson, J. Perheentupa, S. Aranko, R. Pelkonen, and K. J. Krohn. 1994. Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease. J Clin Endocrinol Metab 78:p323.

39. M. Arbuckle, M. McClain, M. Rubertone, and et al. 2003. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 349(1):p526.

40. Ahonen, P., A. Miettinen, and J. Perheentupa. 1987. Adrenal and steroidal cell antibodies in patients with autoimmune polyglandular disease type I and risk of adrenocortical and ovarian failure. J Clin Endocrinol Metab 64:p494.

41. Elder, M., N. Maclaren, and W. Riley. 1981. Gonadal autoantibodies in patients with hypogonadism and/or Addison's disease. J Clin Endocrinol Metab 52:p1137.

42. Betterle, C., M. Volpato, B. Rees Smith, J. Furmaniak, S. Chen, N. A. Greggio, M. Sanzari, F. Tedesco, B. Pedini, M. Boscaro, and F. Presotto. 1997. I. Adrenal cortex and steroid 21-hydroxylase autoantibodies in adult patients with organ-specific autoimmune diseases: markers of low progression to clinical Addison's disease. J Clin Endocrinol Metab 82:p932.

43. Goldstein, D. E., A. Drash, J. Gibbs, and R. M. Blizzard. 1970. Diabetes mellitus: the incidence of circulating antibodies against thyroid, gastric, and adrenal tissue. J Pediatr 77:p304.

44. Winqvist, O., F. A. Karlsson, and O. Kampe. 1992. 21-Hydroxylase, a major autoantigen in idiopathic Addison's disease. Lancet 339:p1559.

45. Baumann-Antczak, A., N. Wedlock, J. Bednarek, Y. Kiso, H. Krishnan, S. Fowler, B. R. Smith, and J. Furmaniak. 1992. Autoimmune Addison's disease and 21-hydroxylase. Lancet 340:p429.

46. Bednarek, J., J. Furmaniak, N. Wedlock, Y. Kiso, A. Baumann-Antczak, S. Fowler, H. Krishnan, J. A. Craft, and B. Rees Smith. 1992. Steroid 21-hydroxylase is a major autoantigen involved in adult onset autoimmune Addison's disease. FEBS Lett 309:p51.

47. Falorni, A., A. Nikoshkov, S. Laureti, E. Grenback, A. L. Hulting, G. Casucci, F. Santeusanio, P. Brunetti, H. Luthman, and A. Lernmark. 1995. High diagnostic accuracy for idiopathic Addison's disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase. J Clin Endocrinol Metab 80:p2752.

48. Volpato, M., L. Prentice, S. Chen, C. Betterle, B. Rees Smith, and J. Furmaniak. 1998. A study of the epitopes on steroid 21-hydroxylase recognized by autoantibodies in patients with or without Addison's disease. Clin Exp Immunol 111:p422.

49. Chen, S., J. Sawicka, L. Prentice, J. F. Sanders, H. Tanaka, V. Petersen, C. Betterle, M. Volpato, S. Roberts, M. Powell, B. R. Smith, and J. Furmaniak. 1998. Analysis of autoantibody epitopes on steroid 21-hydroxylase using a panel of monoclonal antibodies. J Clin Endocrinol Metab 83:p2977.

50. Asawa, T., N. Wedlock, A. Baumann-Antczak, B. R. Smith, and J. Furmaniak. 1994. Naturally occurring mutations in human steroid 21-hydroxylase influence adrenal autoantibody binding. J Clin Endocrinol Metab 79:p372.

51. Song, Y. H., E. Connor, Y. Li, B. Zorovich, P. Balducci, and N. Maclaren. 1994. The role of tyrosinase in autoimmune vitiligo. Lancet 344:1049.

52.K. Brewer, V. Parziale, G. Eisenbarth. 1997. Screening patients with insulin-dependent diabetes mellitus for adrenal insufficiency. N Engl J Med 337:p202.

53. W. Riley, N. Maclaren, M. Neufeld. 1980. Adrenal autoantibodies and Addison disease in insulin-dependent diabetes mellitus. J Pediatr 97:p191.

54. C. Ketchum, W. Riley, N. Maclaren. 1984. Adrenal dysfunction in asymptomatic patients with adrenocortical autoantibodies. J Clin Endocrinol Metab 58:p1166.

55. McNatty, K. P., R. V. Short, E. W. Barnes, and W. J. Irvine. 1975. The cytotoxic effect of serum from patients with Addison's disease and autoimmune ovarian failure on human granulosa cells in culture. Clin Exp Immunol 22:p378.

56. Furmaniak, J., S. Kominami, T. Asawa, N. Wedlock, J. Colls, and B. R. Smith. 1994. Autoimmune Addison's disease--evidence for a role of steroid 21-hydroxylase autoantibodies in adrenal insufficiency. J Clin Endocrinol Metab 79:p1517.

57. Boscaro, M., C. Betterle, M. Volpato, F. Fallo, J. Furmaniak, B. Rees Smith, and N. Sonino. 1996. Hormonal responses during various phases of autoimmune adrenal failure: no evidence for 21-hydroxylase enzyme activity inhibition in vivo. J Clin Endocrinol Metab 81:p2801.

58. Blizzard, R. M., D. Chee, and W. Davis. 1966. The incidence of parathyroid and other antibodies in the sera of patients with idiopathic hypoparathyroidism. Clin Exp Immunol 1:p119.

59. Chapman, C. K., A. R. Bradwell, and P. W. Dykks. 1986. Do parathyroid and adrenal autoantibodies coexist? J Clin Pathol 39:p813.

60. Betterle, C., A. Caretto, M. Zeviani, B. Pedini, and C. Salviati. 1985. Demonstration and characterization of anti-human mitochondria autoantibodies in idiopathic hypoparathyroidism and in other conditions. Clin Exp Immunol 62:p353.

61. Fattorossi, A., G. D. Aurbach, K. Sakaguchi, A. Cama, S. J. Marx, E. A. Streeten, L. A. Fitzpatrick, and M. L. Brandi. 1988. Anti-endothelial cell antibodies: detection and characterization in sera from patients with autoimmune hypoparathyroidism. Proc Natl Acad Sci U S A 85:p4015.

62. Li, Y., Y. H. Song, N. Rais, E. Connor, D. Schatz, A. Muir, and N. Maclaren. 1996. Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism. J Clin Invest 97:p910.

63. M. Alimohammadi, P. Bjorklund, O. Kampe, and et al. 2008. Autoimmune polyendocrine syndrome Type 1 and NALP5, a parathyroid autoantigen. N Engl J Med 358:p1018.

64. Tuomi, T., P. Bjorses, A. Falorni, J. Partanen, J. Perheentupa, A. Lernmark, and A. Miettinen. 1996. Antibodies to glutamic acid decarboxylase and insulin-dependent diabetes in patients with autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 81:p1488.

65. Velloso, L. A., O. Winqvist, J. Gustafsson, O. Kampe, and F. A. Karlsson. 1994. Autoantibodies against a novel 51 kDa islet antigen and glutamate decarboxylase isoforms in autoimmune polyendocrine syndrome type I. Diabetologia 37:p61.

66. Neufeld, M., N. K. Maclaren, and R. M. Blizzard. 1981. Two types of autoimmune Addison's disease associated with different polyglandular autoimmune (PGA) syndromes. Medicine (Baltimore) 60:355.

67. M. Solimena, F. Folli, R. Aparisi, and et al. 1990. Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome. N Engl J Med 322:p1555.

68. Tuomi, T., L. C. Groop, P. Z. Zimmet, M. J. Rowley, W. Knowles, and I. R. Mackay. 1993. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 42:p359.

69. El Rehewy, M., Y. M. Kong, A. A. Giraldo, and N. R. Rose. 1981. Syngeneic thyroglobulin is immunogenic in good responder mice. Eur J Immunol 11:p146.

70. E. Bonifacio, A. Mayr, A. Knopff, A. Ziegler. 2009. Endocrine autoimmunity in families with type 1 diabetes: frequent appearance of thyroid autoimmunity during late childhood and adolescence. Diabetologia 52:p185.

71. Bahn, R. S. 2000. Understanding the immunology of Graves' ophthalmopathy. Is it an autoimmune disease? Endocrinol Metab Clin North Am 29:p287.

72. Kazuo, K., T. Fujikado, G. Ohmi, J. Hosohata, and Y. Tano. 1997. Value of thyroid stimulating antibody in the diagnosis of thyroid associated ophthalmopathy of euthyroid patients. Br J Ophthalmol 81:p1080.

73. Shokeir, M. O., M. R. Pudek, S. Katz, J. Rootman, and D. L. Kendler. 1996. The relationship of thyrotropin receptor antibody levels to the severity of thyroid orbitopathy. Clin Biochem 29:p187.

74. Gerding, M. N., J. W. van der Meer, M. Broenink, O. Bakker, W. M. Wiersinga, and M. F. Prummel. 2000. Association of thyrotrophin receptor antibodies with the clinical features of Graves' ophthalmopathy. Clin Endocrinol (Oxf 52:p267.

75. Zhang, Z. G., M. Salvi, A. Miller, N. Bernard, B. Arthurs, and J. R. Wall. 1992. Restricted tissue reactivity of autoantibodies to a 64-kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy. Clin Immunol Immunopathol 62:p183.

76. Wu, Y. J., E. M. Clarke, and P. Shepherd. 1998. Prevalence and significance of antibodies reactive with eye muscle membrane antigens in sera from patients with Graves' ophthalmopathy and other thyroid and nonthyroid diseases. Thyroid 8:p167.

77. Kubota, S., K. Gunji, B. A. Ackrell, B. Cochran, C. Stolarski, S. Wengrowicz, J. S. Kennerdell, Y. Hiromatsu, and J. Wall. 1998. The 64-kilodalton eye muscle protein is the flavoprotein subunit of mitochondrial succinate dehydrogenase: the corresponding serum antibodies are good markers of an immune-mediated damage to the eye muscle in patients with Graves' hyperthyroidism. J Clin Endocrinol Metab 83:p443.

78. Gunji, K., S. Kubota, J. Swanson, J. Kiljanski, T. Bednarczuk, S. Wengrowicz, M. Salvi, and J. R. Wall. 1998. Role of the eye muscles in thyroid eye disease: identification of the principal autoantigens. Thyroid 8:p553.

79. Gunji, K., S. Kubota, C. Stolarski, S. Wengrowicz, J. S. Kennerdell, and J. R. Wall. 1999. A 63 kDa skeletal muscle protein associated with eye muscle inflammation in Graves' disease is identified as the calcium binding protein calsequestrin. Autoimmunity 29:p1.

80. Gunji, K., A. De Bellis, A. W. Li, M. Yamada, S. Kubota, B. Ackrell, S. Wengrowicz, A. Bellastella, A. Bizzarro, A. Sinisi, and J. R. Wall. 2000. Cloning and characterization of the novel thyroid and eye muscle shared protein G2s: autoantibodies against G2s are closely associated with ophthalmopathy in patients with Graves' hyperthyroidism. J Clin Endocrinol Metab 85:p1641.

81. Hosal, B. M., J. K. Swanson, C. R. Thompson, S. Kubota, K. Gunji, J. S. Kennerdell, and J. R. Wall. 1999. Significance of serum antibodies reactive with flavoprotein subunit of succinate dehydrogenase in thyroid associated orbitopathy. Br J Ophthalmol 83:p605.

82. Tanaka, N., and V. B. Glass. 1970. Effect of prolonged aministration of parietal cell antibodies from patients with atrophic gastritis and pernicious anemia on the parietal cell mass and hydrochloric acid output in rats. Gastroenterology 58:p482.

83. Loveridge, N., L. Bitensky, J. Chayen, T. U. Hausamen, J. M. Fisher, K. B. Taylor, J. D. Gardner, G. F. Bottazzo, and D. Doniach. 1980. Inhibition of parietal cell function by human gammaglobulin containing gastric parietal cell antibodies. Clin Exp Immunol 41:264.

84. Burman, P., S. Mardh, L. Norberg, and F. A. Karlsson. 1989. Parietal cell antibodies in pernicious anemia inhibit H+, K+-adenosine triphosphatase, the proton pump of the stomach. Gastroenterology 96:p1434.

85. E. Baharav, O. Merimski, Y. Shoenfeld and et al. 1996. Tyrosinase as an autoantigen in patients with vitiligo. Clin Exp Immunol 105:p84.)

86. Z. Xie, D. Chen, D. Jiao, and et al. 1999. Vitiligo antibodies are not directed to tyrosinase. Arch Dermatol 135:p417.

87. M. Visseren, A. van Elsas, E. van der Voort, and et al. 1995. CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells. J Immunol 154:p3991.

88. W. Overwijk, D. Lee, D. Surman, and et al. 1999. Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes. Proc Natl Acad Sci USA 96:p2982.

89. L. Austin, R. Boissy. 1995. Mammalian tyrosinase-related protein-1 is recognized by autoantibodies from vitiliginous Smyth chickens: an avian model for human vitiligo. Am J Pathol 146:p1529.

90. Scherbaum, W. A. 1992. Autoimmune hypothalamic diabetes insipidus ("autoimmune hypothalamitis"). Prog Brain Res 93:283.

91. Bottazzo, G. F., A. Pouplard, A. Florin-Christensen, and D. Doniach. 1975. Autoantibodies to prolactin-secreting cells of human pituitary. Lancet 2:p97.

92. Cosman, F., K. D. Post, D. A. Holub, and S. L. Wardlaw. 1989. Lymphocytic hypophysitis. Report of 3 new cases and review of the literature. Medicine (Baltimore) 68:p240.

93.G. Forsberg, O. Hernell, M. Hammarstrom, and et al. 2002. Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease. Gastroenterology 123:p667.

94. Bigazzi, P. E. 1985. Autoimmunity of the adrenals. Marcel Dekker, New York.

95. Volpe, R. 1990. Immunology of human thyroid disease. CRC Press, Boca Raton, Fl.

96. Brenner, O. 1928. Addison's disease with atropy of the cortex of the suprarenals. Q J Med 22:121.

97. Gloor, E., and J. Hurlimann. 1984. Autoimmune oophoritis. Am J Clin Pathol 81:p105.

98. Sedmak, D. D., W. R. Hart, and R. R. Tubbs. 1987. Autoimmune oophoritis: a histopathologic study of involved ovaries with immunologic characterization of the mononuclear cell infiltrate. Int J Gynecol Pathol 6:p73.

99. Bottazzo, G. F., B. M. Dean, J. M. McNally, E. H. MacKay, P. G. Swift, and D. R. Gamble. 1985. In situ characterization of autoimmune phenomena and _expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 313:p353.

100. Foulis, A. K., C. N. Liddle, M. A. Farquharson, J. A. Richmond, and R. S. Weir. 1986. The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 29:p267.

101. Muir, A., and N. K. Maclaren. 1991. Autoimmune diseases of the adrenal glands, parathyroid glands, gonads, and hypothalamic-pituitary axis. Endocrinol Metab Clin North Am 20:619.

102. Schatz, D. A., W. J. Riley, N. K. Maclaren, and D. J. Barrett. 1991. Defective inducer T-cell function before the onset of insulin-dependent diabetes mellitus. J Autoimmun 4:125.

103. Aguayo, J., Y. Sakatsume, C. Jamieson, V. V. Row, and R. Volpe. 1989. Nontoxic nodular goiter and papillary thyroid carcinoma are not associated with peripheral blood lymphocyte sensitization to thyroid cells. J Clin Endocrinol Metab 68:p145.

104. Jarpe, A. J., M. R. Hickman, J. T. Anderson, W. E. Winter, and A. B. Peck. 1990. Flow cytometric enumeration of mononuclear cell populations infiltrating the islets of Langerhans in prediabetic NOD mice: development of a model of autoimmune insulitis for type I diabetes. Reg Immunol 3:p305.

105. J. Yoon, C. Yoon, H. Lim, and et al 1999. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells. Science 284:p1183.

106. Davies, T. F., A. Martin, E. S. Concepcion, P. Graves, L. Cohen, and A. Ben-Nun. 1991. Evidence of limited variability of antigen receptors on intrathyroidal T cells in autoimmune thyroid disease. N Engl J Med 325:p238.

107. Campbell, I. L., and L. C. Harrison. 1990. Molecular pathology of type 1 diabetes. Mol Biol Med 7:p299.

108. Campbell, I. L., A. Cutri, D. Wilkinson, A. W. Boyd, and L. C. Harrison. 1989. Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection. Proc Natl Acad Sci U S A 86:p4282.

109. Bagnasco, M., A. Caretto, D. Olive, B. Pedini, G. W. Canonica, and C. Betterle. 1991. _Expression of intercellular adhesion molecule-1 (ICAM-1) on thyroid epithelial cells in Hashimoto's thyroiditis but not in Graves' disease or papillary thyroid cancer. Clin Exp Immunol 83:p309.

110. Kirkpatrick, C. H. 1980. Transfer factor. CRC Crit Rev Clin Lab Sci 12:p87.

111. Neufeld, M., N. Maclaren, and R. Blizzard. 1980. Autoimmune polyglandular syndromes. Pediatr Ann 9:154.

112. Ahonen, P., S. Myllarniemi, I. Sipila, and J. Perheentupa. 1990. Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. N Engl J Med 322:p1829.

113. Zlotogora, J., and M. S. Shapiro. 1992. Polyglandular autoimmune syndrome type I among Iranian Jews. J Med Genet 29:p824.

114. Hedstrand, H., O. Ekwall, M. J. Olsson, E. Landgren, E. H. Kemp, A. P. Weetman, J. Perheentupa, E. Husebye, J. Gustafsson, C. Betterle, O. Kampe, and F. Rorsman. 2001. The transcription factors SOX9 and SOX10 are vitiligo autoantigens in autoimmune polyendocrine syndrome type I. J Biol Chem 276:p35390.

115. Kemp, E. H., E. A. Waterman, B. E. Hawes, K. O'Neill, R. V. Gottumukkala, D. J. Gawkrodger, A. P. Weetman, and P. F. Watson. 2002. The melanin-concentrating hormone receptor 1, a novel target of autoantibody responses in vitiligo. J Clin Invest 109:p923.

116. Hedstrand H, Ekwall O, Haavik J, Landgren E, Betterle C, Perheentupa J, Gustafsson J, Husebye E, Rorsman F, Kampe O. 2000. Identification of tyrosine hydroxylase as an autoantigen in autoimmune polyendocrine syndrome type I. Biochem Biophys Res Commun. 267:456-461.

117. Ekwall O, Hedstrand H, Grimelius L, Haavik J, Perheentupa J, Gustafsson J, Husebye E, Kampe O, Rorsman F. 1998. Identification of tryptophan hydroxylase as an intestinal autoantigen. Lancet. 352:279-283.

118. Michele TM, Fleckenstein J, Sgrignoli AR, Thuluvath PJ. 1994. Chronic active hepatitis in the type I polyglandular autoimmune syndrome. Postgrad Med J. 70:128-131.

119. Sotsiou F, Bottazzo GF, Doniach D. 1980. Immunofluorescence studies on autoantibodies to steroid-producing cells, and to germline cells in endocrine disease and infertility. Clin Exp Immunol. 39:97-111.188. Betterle C, Dal Pra C, Mantero F, Zanchetta R. 2002. Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev. 23:327-364.

120. Rosatelli, M. C., A. Meloni, M. Devoto, A. Cao, H. S. Scott, P. Peterson, M. Heino, K. J. Krohn, K. Nagamine, J. Kudoh, N. Shimizu, and S. E. Antonarakis. 1998. A common mutation in Sardinian autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients. Hum Genet 103:p428.

121. Scott, H. S., M. Heino, P. Peterson, L. Mittaz, M. D. Lalioti, C. Betterle, A. Cohen, M. Seri, M. Lerone, G. Romeo, P. Collin, M. Salo, R. Metcalfe, A. Weetman, M. P. Papasavvas, C. Rossier, K. Nagamine, J. Kudoh, N. Shimizu, K. J. Krohn, and S. E. Antonarakis. 1998. Common mutations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients of different origins. Mol Endocrinol 12:p1112.

122. Wang, C. Y., A. Davoodi-Semiromi, W. Huang, E. Connor, J. D. Shi, and J. X. She. 1998. Characterization of mutations in patients with autoimmune polyglandular syndrome type 1 (APS1). Hum Genet 103:p681.

123. Bjorses, P., J. Aaltonen, N. Horelli-Kuitunen, M. L. Yaspo, and L. Peltonen. 1998. Gene defect behind APECED: a new clue to autoimmunity. Hum Mol Genet 7:p1547.

124. Heino, M., H. S. Scott, Q. Chen, P. Peterson, U. Maebpaa, M. P. Papasavvas, L. Mittaz, C. Barras, C. Rossier, G. P. Chrousos, C. A. Stratakis, K. Nagamine, J. Kudoh, N. Shimizu, N. Maclaren, S. E. Antonarakis, and K. Krohn. 1999. Mutation analyses of North American APS-1 patients. Hum Mutat 13:69.

125. Bjorses, P., M. Halonen, J. J. Palvimo, M. Kolmer, J. Aaltonen, P. Ellonen, J. Perheentupa, I. Ulmanen, and L. Peltonen. 2000. Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein. Am J Hum Genet 66:p378.

126. Pitkanen, J., V. Doucas, T. Sternsdorf, T. Nakajima, S. Aratani, K. Jensen, H. Will, P. Vahamurto, J. Ollila, M. Vihinen, H. S. Scott, S. E. Antonarakis, J. Kudoh, N. Shimizu, K. Krohn, and P. Peterson. 2000. The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein. J Biol Chem 275:p16802.

127. Spinner, M. W., R. M. Blizzard, and B. Childs. 1968. Clinical and genetic heterogeneity in idiopathic Addison's disease and hypoparathyroidism. J Clin Endocrinol Metab 28:p795.

128. Ahonen, P. 1985. Autoimmune polyendocrinopathy--candidosis--ectodermal dystrophy (APECED): autosomal recessive inheritance. Clin Genet 27:p535.

129. Aaltonen, J., N. Horelli-Kuitunen, J. B. Fan, P. Bjorses, J. Perheentupa, R. Myers, A. Palotie, and L. Peltonen. 1997. High-resolution physical and transcriptional mapping of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy locus on chromosome 21q22.3 by FISH. Genome Res 7:p820.

130. Bjorses, P., J. Aaltonen, A. Vikman, J. Perheentupa, G. Ben-Zion, G. Chiumello, N. Dahl, P. Heideman, J. J. Hoorweg-Nijman, L. Mathivon, P. E. Mullis, M. Pohl, M. Ritzen, G. Romeo, M. S. Shapiro, C. S. Smith, J. Solyom, J. Zlotogora, and L. Peltonen. 1996. Genetic homogeneity of autoimmune polyglandular disease type I. Am J Hum Genet 59:p879.

131. Chen, Q. Y., M. S. Lan, J. X. She, and N. K. Maclaren. 1998. The gene responsible for autoimmune polyglandular syndrome type 1 maps to chromosome 21q22.3 in US patients. J Autoimmun 11:177.

132. Pearce, S. H., T. Cheetham, H. Imrie, B. Vaidya, N. D. Barnes, R. W. Bilous, D. Carr, K. Meeran, N. J. Shaw, C. S. Smith, A. D. Toft, G. Williams, and P. Kendall-Taylor. 1998. A common and recurrent 13-bp deletion in the autoimmune regulator gene in British kindreds with autoimmune polyendocrinopathy type 1. Am J Hum Genet 63:p1675.

133. P. Peterson, L. Peltonen 2005. Autoimmune polyendocrinopathy syndrome type 1 (APS 1) and AIRE gene: new views on molecular basis of autoimmunity. J Autoimmun 25 Suppl:p49.

134. Thenot, S., C. Henriquet, H. Rochefort, and V. Cavailles. 1997. Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1. J Biol Chem 272:p12062.

135. Ge, Q., D. S. Nilasena, C. A. O'Brien, M. B. Frank, and I. N. Targoff. 1995. Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen. J Clin Invest 96:p1730.

136. Woodage, T., M. A. Basrai, A. D. Baxevanis, P. Hieter, and F. S. Collins. 1997. Characterization of the CHD family of proteins. Proc Natl Acad Sci U S A 94:p11472.

137. Le Douarin, B., A. L. Nielsen, J. You, P. Chambon, and R. Losson. 1997. TIF1 alpha: a chromatin-specific mediator for the ligand-dependent activation function AF-2 of nuclear receptors? Biochem Soc Trans 25:p605.

138. R. Burt and et al 2007. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 297: p1568.

139. K. Adamson, S. Pearse, J. Lamb and et al 2002. A comparative study of mRNA and protein expression of the autoimmune regulator gene (Aire) in embryonic and adult murine tissues. J Pathol 202:p180.

140. J. Pitkanen and P. Peterson 2003. Autoimmune regulator from loss of function to autoimmunity. Genes Immun 4:p12.

141. K. Kogawa, S. Nagafuchi, H. Katsuta and et al 2002. Expression of AIRE gene in peripheral monocyte/dendritic cell lineage. Immunol Lett 1:p195.

142. C. Ramsey, O. Winquist, I. Puhakka and et al 2002. Aire deficiency mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11:p397.

143. M. Anderson, E. Venanzi, L. Klein, and et al 2002. Projection of an immunological self shadow within the thymus by the Aire protein. Science 298:p1395.

144. A. Liston, S. Lesage, J. Wilson, and et al 2003. Aire regulates negative selection of organ-specific T cells. Nat Immunol 4:p303.

145. D. Uchida, S. Hatakeyama, A. Matsushuma, and et al 2004. AAIRE functions as an E3 upiquitin ligase. J Exp Med 199:p167.

146. Lukinmaa, P. L., J. Waltimo, and S. Pirinen. 1996. Microanatomy of the dental enamel in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED): report of three cases. J Craniofac Genet Dev Biol 16:p174.

147. Tamai, H., A. Kimura, R. P. Dong, S. Matsubayashi, K. Kuma, S. Nagataki, and T. Sasazuki. 1994. Resistance to autoimmune thyroid disease is associated with HLA-DQ. J Clin Endocrinol Metab 78:p94.

148. Santamaria, P., J. J. Barbosa, A. L. Lindstrom, T. A. Lemke, F. C. Goetz, and S. S. Rich. 1994. HLA-DQB1-associated susceptibility that distinguishes Hashimoto's thyroiditis from Graves' disease in type I diabetic patients. J Clin Endocrinol Metab 78:p878.

150. Boehm, B. O., B. Manfras, S. Seidl, G. Holzberger, P. Kuhnl, C. Rosak, K. Schoffling, and M. Trucco. 1991. The HLA-DQ beta non-Asp-57 allele: a predictor of future insulin-dependent diabetes mellitus in patients with autoimmune Addison's disease. Tissue Antigens 37:p130.

149. Huang, W., E. Connor, T. D. Rosa, A. Muir, D. Schatz, J. Silverstein, S. Crockett, J. X. She, and N. K. Maclaren. 1996. Although DR3-DQB1*0201 may be associated with multiple component diseases of the autoimmune polyglandular syndromes, the human leukocyte antigen DR4-DQB1*0302 haplotype is implicated only in beta-cell autoimmunity. J Clin Endocrinol Metab 81:2559.

151. She, J. X. 1996. Susceptibility to type I diabetes: HLA-DQ and DR revisited. Immunol Today 17:323.

152. Todd, J. A. 1997. Genetics of type 1 diabetes. Pathol Biol (Paris) 45:219.

153. Sale, M. M., T. Akamizu, T. D. Howard, T. Yokota, K. Nakao, T. Mori, H. Iwasaki, S. S. Rich, J. E. Jennings-Gee, M. Yamada, and D. W. Bowden. 1997. Association of autoimmune thyroid disease with a microsatellite marker for the thyrotropin receptor gene and CTLA-4 in a Japanese population. Proc Assoc Am Physicians 109:p453.

154. Yanagawa, T., Y. Hidaka, V. Guimaraes, M. Soliman, and L. J. De Groot. 1995. CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population. J Clin Endocrinol Metab 80:p41.

155. Tomer, Y., G. Barbesino, D. A. Greenberg, E. Concepcion, and T. F. Davies. 1998. A new Graves disease-susceptibility locus maps to chromosome 20q11.2. International Consortium for the Genetics of Autoimmune Thyroid Disease. Am J Hum Genet 63:p1749.

156. Herrod, H. G. 1990. Chronic mucocutaneous candidiasis in childhood and complications of non-Candida infection: a report of the Pediatric Immunodeficiency Collaborative Study Group. J Pediatr 116:p377.

157. J. Aaltonen, Pl Bjorses, L. Sandkuijl, and et al 1994. An autosomal locus causing autoimmune disease: autoimmune polyglandular disease type 1 assigned to chromosome 21. Nat Genet 8:p83.

158. Maclaren, N. K., and R. M. Blizzard. 1985. Adrenal autoimmunity and autoimmune polyglandular syndromes. Academic Press, Orlando.

159. Lonsdale, R. N., P. F. Roberts, and J. E. Trowell. 1991. Autoimmune oophoritis associated with polycystic ovaries. Histopathology 19:p77.

160. Y. Kamai, K. Maebashi, H. Yamaguchi, and et al 2004. Characterization of mechanisms of fluconazole resistance in a Candida albicans isolate from a Japanese patient with chronic mucocutaneous candidiasis. Microbiol Immunol 48:p937.

161. Brun, J. M. 1982. Juvenile autoimmune polyendocrinopathy. Horm Res 16:p308.

162. M. Leshin 1985. Polyglandular autoimmune syndromes. Am J Med Sci 290:p77.

163. M. Dittmar, G. Kahaly 2003. Polyglandular autoimmune syndromes: immunogenetics and long-term follow-up. J Clin Endo Metab 88:p2983.

164. Osserman, K. E. 1969. Muscels (myasthenia gravis). Grune and Stratton, New York.

165. Tsatsoulis, A., and S. M. Shalet. 1991. Antisperm antibodies in the polyglandular autoimmune (PGA) syndrome type I: response to cyclical steroid therapy. Clin Endocrinol (Oxf 35:p299.

166. Mandel, M., A. Etzioni, R. Theodor, and J. H. Passwell. 1989. Pure red cell hypoplasia associated with polyglandular autoimmune syndrome type I. Isr J Med Sci 25:p138.

167. Walz, B., and G. L. From. 1990. Addison's disease and sarcoidosis: unusual frequency of co-existing hypothyroidism (Schmidt's syndrome). Am J Med 89:p692.

168. Vela, B. S., R. I. Dorin, and M. F. Hartshorne. 1990. Case report 631: Neo-osseous porosis (metaphyseal osteopenia) in polyglandular autoimmune (Schmidt) syndrome. Skeletal Radiol 19:p468.

169. Hall, J. G., and D. M. Gilchrist. 1990. Turner syndrome and its variants. Pediatr Clin North Am 37:p1421.

170. Ketchum, C. H., W. J. Riley, and N. K. Maclaren. 1984. Adrenal dysfunction in asymptomatic patients with adrenocortical autoantibodies. J Clin Endocrinol Metab 58:p1166.

171. Martin, S., G. Schernthaner, J. Nerup, F. A. Gries, V. A. Koivisto, J. Dupre, E. Standl, P. Hamet, R. McArthur, M. H. Tan, and et al. 1991. Follow-up of cyclosporin A treatment in type 1 (insulin-dependent) diabetes mellitus: lack of long-term effects. Diabetologia 34:p429.

172. Silverstein, J., N. Maclaren, W. Riley, R. Spillar, D. Radjenovic, and S. Johnson. 1988. Immunosuppression with azathioprine and prednisone in recent-onset insulin-dependent diabetes mellitus. N Engl J Med 319:599.

173. J. Nerum 1974. Addison’s disease—clinical studies. A report of 108 cases. Acta Endocrin (Copenh) 76:p127.

174. Rabinowe, S. L., M. J. Berger, W. R. Welch, and R. G. Dluhy. 1986. Lymphocyte dysfunction in autoimmune oophoritis. Resumption of menses with corticosteroids. Am J Med 81:p347.

175. Mayfield, R. K., J. H. Levine, L. Gordon, J. Powers, R. M. Galbraith, and S. E. Rawe. 1980. Lymphoid adenohypophysitis presenting as a pituitary tumor. Am J Med 69:p619.

176. Sutherland, D. E. 1991. Current status of pancreas transplantation. J Clin Endocrinol Metab 73:461.

177. L. Ward and et al 1999. Severe autoimmune polyendocrinopathy-Candidiasis-ectodermal dystrophy in an adolescent girl with a novel AIRE mutation: response to immunosuppressive therapy. J Clin Endo 84:p844.

178. Stavinoha, M. W., and R. D. Soloway. 1990. Current therapy of chronic liver disease. Drugs 39:p814.

179. A. Meager and et al 2006. Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLoS Med 3:p1152.

180. Vaidya B, Pearce S. 2004. The emerging role of the CTLA-4 gene in autoimmune endocrinopathies. Eur J Endocrinol. 150:619-626.

181. Aanstoot, H. J., S. M. Kang, J. Kim, L. A. Lindsay, U. Roll, M. Knip, M. Atkinson, P. Mose-Larsen, S. Fey, J. Ludvigsson, and et al. 1996. Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes. J Clin Invest 97:2772.

182. Palmer, J. P., C. M. Asplin, P. Clemons, K. Lyen, O. Tatpati, P. K. Raghu, and T. L. Paquette. 1983. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222:1337.

183. Flier, J. S., C. R. Kahn, D. B. Jarrett, and J. Roth. 1976. Characterization of antibodies to the insulin receptor: a cause of insulin-resistant diabetes in man. J Clin Invest 58:1442.

184. Johnson, J. H., A. Ogawa, L. Chen, L. Orci, C. B. Newgard, T. Alam, and R. H. Unger. 1990. Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes [published erratum appears in Science 1990 Nov 30; 250(4985):1195]. Science 250:546.

185. Roitt, I. M., and D. Doniach. 1967. A reaccessment of studies on the aggregation of thyroid autoimmunity in families of thyroiditis patients. Clin. Expt. Immunol. 2:727.

186. McKenzie, J. M. 1968. Humoral factors in the pathogenesis of Graves' disease. Physiol Rev 48:252.

187. Furmaniak, J., S. Kominami, T. Asawa, N. Wedlock, J. Colls, and B. R. Smith. 1994. Autoimmune Addison's disease--evidence for a role of steroid 21-hydroxylase autoantibodies in adrenal insufficiency. J Clin Endocrinol Metab 79:1517.

188. Song, Y. H., J. Y. Ma, S. Mardh, T. Liu, S. E. Sjostrand, L. Rask, K. Borch, G. C. Huang, P. Barnett, A. M. McGregor, and et al. 1994. Localization of a pernicious anaemia autoantibody epitope on the alpha-subunit of human H,K-adenosine triphosphatase. Scand J Gastroenterol 29:122.

189. Dieterich, W., T. Ehnis, M. Bauer, P. Donner, U. Volta, E. O. Riecken, and D. Schuppan. 1997. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3:797.

190. Kifor O, McElduff A, LeBoff MS, Moore FD Jr, Butters R, Gao P, Cantor TL, Kifor I, Brown EM. 2004. Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab. 89:548-556.

191. Skoldberg F, Rorsman F, Perheentupa J, Landin-Olsson M, Husebye ES, Gustafsson J, Kampe O. J. 2004. Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease. Clin Endocrinol Metab. 89:1636-1640.

192. Bjork E, Velloso LA, Kampe O, Karlsson FA. 1994. GAD autoantibodies in IDDM, stiff-man syndrome, and autoimmune polyendocrine syndrome type I recognize different epitopes. Diabetes.43:161-165.

193. Clemente MG, Obermayer-Straub P, Meloni A, Strassburg CP, Arangino V, Tukey RH, De Virgiliis S, Manns MP. 1997. Cytochrome P450 1A2 is a hepatic autoantigen in autoimmune polyglandular syndrome type 1. J Clin Endocrinol Metab. 82:1353-1361.

194. Halonen M, Eskelin P, Myhre AG, Perheentupa J, Husebye ES, Kampe O, Rorsman F, Peltonen L, Ulmanen I, Partanen J. 2002. AIRE mutations and human leukocyte antigen genotypes as determinants of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy phenotype.J Clin Endocrinol Metab.87:2568-2574.

195. Soderbergh A, Myhre AG, Ekwall O, Gebre-Medhin G, et al. 2004. Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab. 89:557-562.

196. Friedman TC, Thomas PM, Fleisher TA, Feuillan P, Parker RI, Cassorla F, Chrousos GP. 1991. Frequent occurrence of asplenism and cholelithiasis in patients with autoimmune polyglandular disease type I. Am J Med. 91:625-630

197. W.Dieterich, T. Ehnis, M. Bauer, and et al. 1997. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3:p797.

198. A. Picarelli, L. Maiuri, A. Frate, and et al. 1996. Production of anti-endomysial antibodies after in-vitro gliadin challenge of small intestine biopsy samples from patients with celiac disease. Lancet 348:p1065.

199. M. Maki. 1996. Celiac disease and autoimmunity due to unmasking of cryptic epitopes. Lancet 348:p1046.

200. Kaufman, D. L., M. Clare-Salzler, J. Tian, T. Forsthuber, G. S. Ting, P. Robinson, M. A. Atkinson, E. E. Sercarz, A. J. Tobin, and P. V. Lehmann. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366:69.

201. Lu, J., Q. Li, H. Xie, Z. J. Chen, A. E. Borovitskaya, N. K. Maclaren, A. L. Notkins, and M. S. Lan. 1996. Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci U S A 93:2307.

202. Lan, M. S., C. Wasserfall, N. K. Maclaren, and A. L. Notkins. 1996. IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A 93:6367.

203. Maclaren, N. Pending publication, updated 2009. Autoimmune polyglandular syndromes. Endocrinology 6thEd, DeGroot and Jameson, Chapter 149:Part XV.