Based on the rapid progression and severity of symptoms, you are concerned for a more sinister cause. Which of the following laboratory tests is most likely to differentiate between an adrenal or ovarian source of excess androgens?
Total Testosterone levels are elevated in all women with androgen-secreting tumors. As testosterone comes from ovaries as well as from peripheral conversion of androstenedione –the levels cannot be used to differentiate the source of hyperandrogenism, i.e. ovarian vs. adrenal.