Figure 1. Molecular events of Familial Hyperaldosteronism Type I (FH-I) or Glucocorticoid Remediable Aldosteronism (GRA). Fusion of CYP11B1 encoding for 11β-hydroxylase, and the CYP11B2 that expresses aldosterone synthase results in a chimeric gene leading to ACTH-dependent aldosterone secretion.