Fig 16. Markers of bone turnover during 18 months of GH (▲) treatment in a randomized, placebo- controlled (O), double blinded study. Values are given as means (^S.E.). The P values for differences of change from baseline between GH- and placebo-treated patients are *P, 0:05; **P, 0:01; ***P, 0:001; ****P, 0:0001: Creat, creatinine. From: Sneppen et al (189).