Figure 17. Markers of bone turnover during 18 months of GH (V) treatment in a randomised, placebo- controlled (O), double blinded study. Values are given as means (^S.E.). The P values for differences of change from baseline between GH- and placebo-treated patients are *P , 0:05; **P , 0:01; ***P , 0:001; ****P , 0:0001: Creat, creatinine.   From: Sneppen et al. (178)