Figure 10. Structure of the ligand binding domain of the human androgen receptor. A) The crystal structure of the LBD with DHT bound (pdb 1137). Specific amino acid- hormone interactions are illustrated in the right-hand panel. B) The LBD structure with the synthetic agonist R1881 and a coactivator peptide with an FxxLF motif bound to AF2 region (pink oval) (pdb 1XOW). C) Structure of the LBD showing the location of the BF3 pocket (blue oval) with triiodothyroacetic acid/TRIAC bound (pdb 2PKL).