Figure 6. Pharmacologic therapy algorithm for type-2 diabetes mellitus. First- and second-line pharmacologic agents in the management of type-2 diabetes mellitus (T2DM). ASCVD, atherosclerotic cardiovascular disease; GLP1-RA, glucagon-like peptide-1 receptor agonists; HbA1c, hemoglobin A1c, SGLT2i, sodium-glucose co-transporter -2 inhibitors. * In patients with HFrEF or kidney disease a SGLT2i is indicated regardless of HbA1c level. In patients with ACSVD a GLP1-RA or SGLT2i is indicated regardless of HbA1c level.