Figure 1. Schematic representation of the central and peripheral mechanisms of antipsychotic-induced weight gain and metabolic side effects as well as current and future preventive and therapeutic options. HPA axis: hypothalamic–pituitary–adrenal axis, GLP-1: glucagon like peptide-1, GLP1RA: GLP-1 receptor agonist, RMR: resting metabolic rate, IL6: interleukin-6, TNF-α: tumor necrosis factor-α, IR: insulin resistance, PKC-βi: protein kinase C-β inhibitor, CB1R: cannabinoid receptor type 1, periph CB1Ri: peripheral cannabinoid receptor type 1 inhibitor, SREBP1c: sterol regulatory element-binding proteins type 1c, AMPK: AMP-activated protein kinase (Reprinted by permission from Springer Nature Customer Service Centr GmbH: J Endocrinol Invest. 2017;40(11):1165-1174) (2).