![](https://www.endotext.org/wp-content/uploads/2014/08/gut2-fig38.png)
Figure 38. mTOR mediates downstreaming signaling from IGFi/SSA, VEGFi and VEGF TKIs which is responsible for angiogenesis, bioenergy, growth and proliferation of cell. Activation of mTOR pathway occurs through PI3K/AKT/RAS. While inhibitors of mTOR pathway includes PTEN/NF1. Inactivation of mTOR pathway alone or combined with RAD001 therapy is implicated in inhibition of neuroendocrine tumor growth.