Figure 16. Interaction model of the Gas5 RNA “GRE” to GR DBD and the molecular actions of Gas5 on GR-induced transcriptional activity. A: 3-Dimenstional structure of Gas5 “GRE”-mimic and its interaction model with GR DBD. From (342). B: Schematic model of Gas5 molecular actions on GR-induced transcriptional activity. Gas5 accumulated in response to growth arrest/starvation binds GR DBD and attenuates GR-induced transcriptional activity by competing with DNA GREs located in the promoter region of glucocorticoid-responsive genes.