Figure 8. Intracellular circulation of GR. Circulation of GR between the cytoplasm and the nucleus, and its transcriptional regulation on the glucocorticoid-responsive genes in the nucleus are shown in the panel. GR translocates into mitochondria or lysosomes as well. GREs: glucocorticoid responsive elements; TFREs: transcription factor responsive elements; HSPs: heat shock proteins; TF: transcription factor. From (59).