3B: 3-Dimensional model of the physical interaction between the GR DBD and GRE DNA. The N-terminal’s first -helix of the GR DBD lies in the major groove of the double-stranded DNA, while the C-terminal part of each module is positioned over the minor groove. The image was created and kindly donated by Dr. D.E. Hurt (National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD)