Figure 5: GR isoforms produced through alternative splicing or use of different translational initiation sites.
The GR gene contains two terminal exons 9 (9 and 9) alternatively spliced to produce the classic GR (GR-A) and GR-A. C-terminal dark yellow colored domains in GR-A and GR-A show their specific portions. Using at least 8 different translation initiation sites located in NTD, the GR gene produces multiple GR isoforms termed A through D (A, B, C1-C3 and D1-D3) with distinct transcriptional activities on glucocorticoid-responsive genes. Since GR and GR share a common mRNA domain that contains the same translation initiation sites, the GR variant mRNA appears to be also translated through the same initiation sites and to produce 8 isoforms with different lengths NTD. Modified from (36, 362).
AF-1 and -2: activation function 1 and 2; DBD; DNA-binding domain; HD: hinge region; LBD: Ligand-binding domain