Figure 8: Schematic model demonstrating the interaction and activity of coactivators and other chromatin modulators, attracted by GRa to the promoter region of glucocorticoid-responsive genes. Promoter-associated GRa is cleared by the ubiquitin-proteasomal pathway, which regulates turnover of GRa on DNA. Modified from (364).

AF-1 and 2: activation function 1 and 2; CBP: cAMP-responsive element-binding protein (CREB)-binding protein; DRIP: vitamin D receptor-interacting protein; GR: glucocorticoid receptor; GREs: glucocorticoid response elements; p/CAF: p300/CBP-associated factor; SWI/SNF: mating-type switching/sucrose non-fermenting TRAP: thyroid hormone receptor-associated protein.