Figure 11: GR binds nGREs as a monomer.
GR binds nGREs as a monomer at each of its half site (A) in contrast to its binding as a homo-dimer to classic GREs (B). nGREs of the mouse TSLP gene is used as an example.
Images are from the PDB Website (www.rcsb.org). Image data for GR interaction with nGREs and classic GREs are DOI: 10.2210/pdb4hn5/pdb and DOI: 10.2210/pdb3g9m/pdb, respectively.