Figure 9: GRa binds nGREs as a monomer.

GRa binds nGREs as a monomer at each of its half site (A) in contrast to its binding as a homo-dimer to classic GREs (B). nGREs of the mouse TSLP gene is used as an example.

Images are from RCSB Protein Data Bank (PDB) Website ( Image data for GRa interaction with nGREs and classic GREs are DOI: 10.2210/pdb4hn5/pdb and DOI: 10.2210/pdb3g9m/pdb, respectively.