Figure 3.Human proglucagon with differential processing in pancreatic alpha cells and intestinal L cells. In the alpha cells, the major products released into plasma are glicentin related polypeptide, glucagon, a minor and a major proglucagon fragment whereas in the intestinal L cells, the major products released are glicentin, GLI-1 (glucagon-like peptide-1) and GLP-2 (glucagon-like peptide-2). (Copyright 2001 by McGraw-Hill Companies. Reproduced with permission of McGraw-Hill Companies from Masharani U and Karam JH: Pancreatic hormones and diabetes mellitus. In: Basic & Clinical Endocrinology. Greenspan FS and Gardner DG eds. New York: McGraw-Hill, 2001, pp. 623-698.)