![](https://www.endotext.org/wp-content/uploads/2017/10/etx-pit-ch5-fig2.png)
Figure 2. Diagram showing the release of ACTH from corticotroph cells. CRH binds to a particular receptor that leads to activation of cAMP. The rise in cAMP inhibits TREK-1, thus leading to the depolarization of the cell and subsequently influx of calcium via VGCC. The rise in intracellular calcium leads to the exocytosis and release of ACTH.