Figure 2.The adverse effects of high glucose on pancreatic Î²-cell function have been described in the partial pancreatectomy rat model. The changes in function and structure have been divided into 4 phases. Phase 1 is â€œsuccessful adaptationâ€ and occurs from 0 â€“ 3 weeks post-pancreatectomy. Phase 2 is â€œmild decompensationâ€ and occurs between week 2 and 8. Phase 3 is â€œsevere decompensationâ€ and is observed between week 6 â€“ 16. Phase 4 is â€œÎ²-cell failure with structural damageâ€ and occurs between week 12 â€“ 30. (See text for details).