Figure 3b-5: Mixed densely and sparsely granulated somatotroph adenoma. A proportion of somatotroph adenomas demonstrate a clearly segregated mixed densely-sparsely phenotype. The respective cells remain true to their ‘pure’ counterparts: The sparsely granulated cells can be identified as chromophobe islands amongst orangeophilic densely granulated cells (left) and their contrasting cytokeratin pattern is absolutely clear following incubation with Cam5.2 antibody (right).