Figure 3 Illustrates the almost totipotentiality of the protodifferentiated pancreatic stem cell to differentiate into a variety of cell types to produce an almost infinite variety of clinical syndromes EC=enterochromaffin, GHRH= growth hormone releasing hormone, VIP = vasoactive intestinal polypeptide, CGRP= calcitonin releasing peptide, HHM = humoral hypercalcemic factor of malignancy, IGF = insulin like growth factor, INGAP = islet neogenesis growth associated peptide.