![](https://www.endotext.org/wp-content/uploads/2018/08/etx-pit-ch6-fig3.png)
Figure 3. Neuroendocrine regulation of GnRH/gonadotropin secretion. The GnRH-gonadotropin system plays a central role in the regulation of reproduction by integrating different neuroendocrine, metabolic and environmental signals/factors. The KNDy signaling has a key role in this process by integrating some of these signals and by regulating GnRH neurons.