Figure 3B: Location of the known mutations of the glucocorticoid receptor (hGR) gene ( A ) and protein ( B ). AF: activation function; DBD: DNA-binding domain; GR: glucocorticoid receptor; GREs: glucocorticoid response elements; HSP: heat shock protein; NTD: amino terminal domain; LBD: ligand-binding domain. Adapted from Reference 31.