FIGURE 30. Respective roles of testosterone(T) and dihydrotestosterone (DHT) in sex differentiation. Normal androgen physiology in mammals. Testosterone and dihydrotestosterone are assumed to work by binding to the same receptor protein and forming hormone–receptor complexes of different allosteric configurations. Abbreviations: AR, androgen receptor; 17β-HSD3, 17β-hydroxysteroid dehydrogenase type 3; LHR, luteinizing hormone receptor; 5α-R2, steroid 5α-reductase type 2. Reprinted from ref. (531): Wilson JD, Shaw G, Leihy ML, Renfree MB. The marsupial model for male phenotypic development. Trends in Endocrinology and Metabolism, 13:78-83 (2002), Copyright 2002, with permission from Elsevier.