Fig27 BOTTOM-Steroidogenesis

FIGURE 27. Steroidogenesis.

Steroidogenesis: the “classic” and “backdoor” pathways for dihydrotestosterone (DHT) synthesis. See Table 6 for enzyme nomenclature. DHEA: dehydroepiandrosterone, DHP: dihydroprogesterone.

Reprinted from ref. 382: Fluck CE, Meyer-Boni M, Pandey AV, Kempna P, Miller WL, Schoenle EJ, Biason-Lauber A. Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation. American Journal of Human Genetics 89:201-218 (2011). Copyright 2011, with permission from Elsevier. (top figure), and ref. 383: Wilson JD, Shaw G, Leihy ML, Renfree MB. The marsupial model for male phenotypic development. Trends in Endocrinology and Metabolism, 13:78-83 (2002), Copyright 2002, with permission from Elsevier. (bottom figure).