Figure 3. Values of sex hormone-binding globulin (SHBG) and carboxyterminal cross-linked telopeptide of type 1 collagen (ICTP) in patients with PRTH or TSH-omas. Shaded areas represent the normal ranges either in premenopausal women or in postmenopausal women and men. The combined measurement of parameters from different tissues may be useful for the differential diagnosis and by-pass possible interference by different factors (age, liver or bone diseases, combined alteration of pituitary functions, treatments, etc.). Tx TSH-omas, treated TSH-omas.