GR Figure 18

Figure 18: Location of the known human GR mutations causing Chrousos syndrome or its mirror image, sporadic glucocorticoid hypersensitivity, in the human GR (NR3C1) gene (A) and in the linearized hGR protein molecule (B).
Nucleoside numbers of the mutated sites are determined by the definition employing adenine of the translation initiation site as number 1. Modified from (382).