Figure 1: (A) Genomic and complementary DNA, and protein structures of the human (h) GR and the isoforms produced through alternative splicing. The hGR gene consists of 10 exons. Exon 1 is an untranslated region, exon 2 codes for the immunogenic domain (NTD), exon 3 and 4 for the DNA-binding domain (DBD), and exons 5-9 for the hinge region (HR) and the ligand-binding domain (LBD). The hGR gene contains two terminal exons 9 (exon 9  and 9β) alternatively spliced to produce the classic hGR  and the nonligand-binding hGRβ.