Figure 1: (B) Functional domains of the hGR  . The functional domains and subdomains are indicated beneath the linearized protein structures. AF-1 and -2: activation function 1 and 2; DBD; DNA-binding domain; HD: hinge region; HSP: Heat shock proteins; LBD: Ligand-binding domain; NTD: N-terminal region, NL1 and 2: Nuclear translocation signal 1 and 2. Adapted from Reference 31.