Fig. 37.Schematic drawing showing major pathways of the temperature control center. Heat sensors in the median preoptic hypothalamus (MnPO) project to neurons in the hypothalamic paraventricular nucleus (PVN) and dorsomedial nucleus (DMN) or directly to the raphe pallidus (RPa) in the brainstem to control autonomic responses mediated through preganglionic neurons in the spinal cord.