Figure 11. Mechanism of insulin-stimulated glucose transport and GLUT4 translocation. This cartoon illustrates the stimulation of GLUT4 translocation from intracellular storage vesicles (GSVs) to the plasma membrane by the IRS/PDK1/AKT2/ signaling cascade, acting on the GTPase-activating protein AS160 which activates the small G protein RAB. Atypical PKCs are also involved. From reference 1, used with permission.